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1
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2
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Voltage-sensitive and solvent-sensitive processes in ion channel gating. Kinetic effects of hyperosmolar media on activation and deactivation of sodium channels.离子通道门控中的电压敏感和溶剂敏感过程。高渗介质对钠通道激活和失活的动力学影响。
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本文引用的文献

1
Gating current harmonics. III. Dynamic transients and steady states with intact sodium inactivation gating.门控电流谐波。III. 具有完整钠失活门控的动态瞬变和稳态。
Biophys J. 1986 Sep;50(3):489-502. doi: 10.1016/S0006-3495(86)83486-5.
2
Gating current harmonics. II. Model simulations of axonal gating currents.门控电流谐波。II. 轴突门控电流的模型模拟。
Biophys J. 1985 Sep;48(3):391-400. doi: 10.1016/S0006-3495(85)83795-4.
3
Gating current harmonics. I. Sodium channel activation gating in dynamic steady states.门控电流谐波。I. 动态稳态下的钠通道激活门控
Biophys J. 1985 Sep;48(3):375-90. doi: 10.1016/S0006-3495(85)83794-2.

门控电流谐波。IV. 钠通道门控中二次激活动力学的动态特性。

Gating current harmonics. IV. Dynamic properties of secondary activation kinetics in sodium channel gating.

作者信息

Fohlmeister J F, Adelman W J

出版信息

Biophys J. 1987 Feb;51(2):335-8. doi: 10.1016/S0006-3495(87)83339-8.

DOI:10.1016/S0006-3495(87)83339-8
PMID:2435332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1329894/
Abstract

The kinetics for sodium channel gating appear to involve three coupled processes: (a) "primary" activation, (b) "secondary" activation, and (c) inactivation. Gating current data obtained in dynamic steady states with sinusoidal voltage-clamp were analyzed to give further details about the secondary activation process in sodium channel gating. Unlike primary activation and inactivation, the secondary activation kinetics involve physical processes that become defined when the data are analyzed as a function of the sinusoid frequency in addition to mean membrane potential. The effects of these processes are described, and a physical interpretation is presented.

摘要

钠通道门控动力学似乎涉及三个耦合过程

(a)“初级”激活，(b)“次级”激活，以及(c)失活。对在动态稳态下使用正弦电压钳获得的门控电流数据进行分析，以进一步了解钠通道门控中的次级激活过程。与初级激活和失活不同，次级激活动力学涉及的物理过程，在将数据作为正弦频率和平均膜电位的函数进行分析时才得以明确。描述了这些过程的影响，并给出了物理解释。