Díez J, Tamargo J
Br J Pharmacol. 1987 Feb;90(2):309-14. doi: 10.1111/j.1476-5381.1987.tb08960.x.
The effect of somatostatin (SS, 10(-6) M and 5 X 10(-6) M) was studied on 45Ca fluxes in guinea-pig isolated atria. SS produced a dose-dependent decrease in 45Ca uptake, this effect being dependent on the stimulation rate and Ca concentration in the bathing media. The decrease in 45Ca uptake was more evident at faster (60 and 180 beats min-1) than at slower frequencies (15 beats min-1) and was less evident in high Ca (5.4 mM). SS had no effect on 45Ca efflux. These results suggest that SS inhibits the slow inward Ca current in guinea-pig atrial fibres.
研究了生长抑素（SS，10⁻⁶ M和5×10⁻⁶ M）对豚鼠离体心房45Ca通量的影响。SS使45Ca摄取呈剂量依赖性减少，这种效应取决于刺激频率和浴液中的钙浓度。在较快频率（60和180次/分钟）时，45Ca摄取的减少比在较慢频率（15次/分钟）时更明显，而在高钙（5.4 mM）时则不太明显。SS对45Ca外流没有影响。这些结果表明，SS抑制豚鼠心房纤维中的慢内向钙电流。
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