氨基糖苷类抗生素对豚鼠心房结合钙及收缩的影响。
Effects of aminoglycoside antibiotics on bound calcium and contraction in guinea-pig atria.
作者信息
Lüllmann H, Schwarz B
出版信息
Br J Pharmacol. 1985 Dec;86(4):799-803. doi: 10.1111/j.1476-5381.1985.tb11101.x.
We studied the effect of three aminoglycoside antibiotics which have been shown to replace Ca from lipid monolayers on the superficially bound Ca of isolated beating left atria from guinea-pigs. The cellular Ca content was determined by means of 45Ca after having attained complete exchange. The antibiotics dibekacin, sisomicin, and gentamicin, all reduced the cellular Ca content by 10-20% in a dose-dependent manner. The loss of superficially bound Ca was accompanied by a decline of the contractile force by 40-90%. It is concluded that in isolated atrial muscle it is the amount of Ca bound to the outer surface of the cardiac plasmalemma, rather than the extracellular Ca2+ concentration, that determines contraction height.
我们研究了三种氨基糖苷类抗生素对豚鼠离体搏动左心房表面结合钙的影响，这些抗生素已被证明能从脂质单层中取代钙。在实现完全交换后，通过45Ca测定细胞钙含量。抗生素地贝卡星、西索米星和庆大霉素均以剂量依赖方式使细胞钙含量降低10 - 20%。表面结合钙的丧失伴随着收缩力下降40 - 90%。得出的结论是，在离体心房肌中，决定收缩高度的是与心肌质膜外表面结合的钙量，而非细胞外Ca2+浓度。
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