新生儿惊厥，在 Multan 的儿童医院和儿童健康研究所的经验。
Neonatal seizures, experience at Children Hospital and Institute of Child Health Multan.
机构信息
Dr. Abdur Rehman Malik, MBBS, DCH, FCPS (Pediatrics), Senior Registrar, Department of Neonatology, Children Hospital and Institute of Child Health, Multan, Pakistan.
Dr. Ahmed Iqbal Quddusi, MBBS, FCPS (Pediatrics), Assistant Professor and Head of Department of Neonatology,Children Hospital and Institute of Child Health, Multan.
出版信息
Pak J Med Sci. 2013 Sep;29(5):1128-31. doi: 10.12669/pjms.295.3847.
OBJECTIVE
The study was conducted to determine the etiology of seizures in neonates.
METHODS
This was a descriptive Cross-sectional study. This study was conducted at neonatal unit of children hospital and institute of child health Multan from June 2012 to April 2013. A total of 285 neonates who presented with seizures were enrolled for the possible causes. First line investigations including blood glucose, serum calcium, serum magnesium, serum sodium, complete blood counts, serum creatinine, liver function tests, ABGs, cerebrospinal fluid examination, cranial ultrasound and EEG were done in all neonates. Second line investigations (blood culture, CT scan, MRI, screening for inborn error of metabolism and Torch antibody titer) were done in selected neonates. The data was analyzed using SPSS-10.
RESULTS
Out of 285 neonates, 175(61.4%) were male and 110(38.6%) female. There were 199(69.8%) term and 86 (30.2%) preterm. Birth asphyxia was the commonest cause of seizures and present in 53.7% neonates and metabolic disturbance in 17.5%. Seizures with unknown etiology were present in 5.3% neonates.
CONCLUSION
In most of the cases, the causes of neonatal seizures were present. Birth asphyxia was the main etiology identified. However, to establish the exact cause of seizures, more extensive work up is needed.
目的
本研究旨在确定新生儿惊厥的病因。
方法
这是一项描述性的横断面研究。本研究于 2012 年 6 月至 2013 年 4 月在儿童医院和儿童健康研究所的新生儿病房进行。共纳入 285 例有惊厥发作的新生儿，以确定可能的病因。所有新生儿均进行一线检查，包括血糖、血清钙、血清镁、血清钠、全血细胞计数、血清肌酐、肝功能检查、ABGs、脑脊液检查、头颅超声和脑电图。在选定的新生儿中进行二线检查（血培养、CT 扫描、MRI、先天性代谢缺陷筛查和 Torch 抗体滴度）。使用 SPSS-10 对数据进行分析。
结果
285 例新生儿中，男 175 例（61.4%），女 110 例（38.6%）；其中足月儿 199 例（69.8%），早产儿 86 例（30.2%）。新生儿惊厥最常见的病因是出生窒息，占 53.7%，代谢紊乱占 17.5%。病因不明的惊厥占 5.3%。
结论
在大多数情况下，新生儿惊厥的病因已明确。出生窒息是确定的主要病因。然而，要确定惊厥的确切病因，需要进行更广泛的检查。
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