Mussavi Mirhadi, Khanzadeh Shokoufeh, Sadeghvand Shahram, Hasanpour Eslam, Akbari Morteza, Nasiri Shahram, Valaei Fateme
Department of Pediatrics, Pediatric Health Researches Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Iran J Child Neurol. 2022 Summer;16(3):183-191. doi: 10.22037/ijcn.v17i1.34950. Epub 2022 Jul 16.
This study aimed to determine the frequency of different types, causes, and abnormal findings of brain computed tomography scan (CT scan) and ultrasonography (US) and multichannel- electroencephalography (EEG) in neonates with seizure. The ability of brain CT scan was also compared with US in terms of detecting the underlying causes of neonatal seizures.
MATERIALS & METHODS: In this cross-sectional retrospective study, the medical records of 90 neonates younger than 28 days with the definite diagnosis of seizure were reviewed. The data were analyzed using SPSS 22 through descriptive and Exact fisher tests.
Totally, 90 newborns (M: F = 1.5:1) with mean age of 63.11 ± 32.8 days were enrolled. 35.5% of newborns were born before the 37 week of pregnancy. In this study, 45.6% of EEG findings, 22% of brain CT scan findings, and 12.5% of US findings were abnormal. The automatisms (38.9%) and benign idiopathic neonatal seizure (70.7%) were the most common seizure type and cause respectively. The hypoxic Ischemic encephalopathy was the most common abnormal finding (30%) in brain CT scan.
Given the accuracy of EEG in detection of brain pathologies, where available, all neonatal seizures should be initially confirmed using EEG. Radiologic investigations (CT scan, US) off the head/ cranium should be done to detect the cause of neonatal seizure. The capacity of brain CT scan to detect underlying causes of neonatal seizures is more than US.
本研究旨在确定癫痫新生儿脑计算机断层扫描（CT扫描）、超声检查（US）和多通道脑电图（EEG）的不同类型、病因及异常发现的频率。还比较了脑CT扫描与超声在检测新生儿癫痫潜在病因方面的能力。
在这项横断面回顾性研究中，回顾了90例确诊为癫痫的28日龄以下新生儿的病历。使用SPSS 22通过描述性和精确费舍尔检验对数据进行分析。
共纳入90例新生儿（男：女 = 1.5:1），平均年龄为63.11±32.8天。35.5%的新生儿在妊娠37周前出生。在本研究中，EEG检查结果异常的占45.6%，脑CT扫描结果异常的占22%，超声检查结果异常的占12.5%。自动症（38.9%）和良性特发性新生儿癫痫（70.7%）分别是最常见的癫痫类型和病因。缺氧缺血性脑病是脑CT扫描中最常见的异常发现（30%）。
鉴于EEG在检测脑部病变方面的准确性，在可行的情况下，所有新生儿癫痫应首先通过EEG进行确诊。应进行头颅/颅骨的放射学检查（CT扫描、超声）以检测新生儿癫痫的病因。脑CT扫描检测新生儿癫痫潜在病因的能力高于超声。
