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化疗后骨髓再生不良的急性髓系白血病患者并发洋葱伯克霍尔德菌败血症。

Burkholderia cepacia septicemia in a patient with acute myeloid leukemia in postchemotherapy bone marrow aplasia.

机构信息

Romeo-Gabriel Mihaila, MD, PhD, University of Sibiu, Faculty of Medicine, Str Lucian Blaga, nr 2A, Sibiu, 550169 Sibiu, Romania.

Lucian Blaga, University of Sibiu, Faculty of Medicine, Str Lucian Blaga, nr 2A, Sibiu, 550169 Sibiu, Romania.

出版信息

Pak J Med Sci. 2013 Sep;29(5):1275-7. doi: 10.12669/pjms.295.3485.

DOI:10.12669/pjms.295.3485
PMID:24353735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3858923/
Abstract

The patients with hematologic malignancies are predisposed to develop infections with unusual bacteria, like Burkholderia cepacia, which is frequently resistant to many antibiotics and antiseptics. We present the case of a female patient with acute myeloid leukemia type 2 on the background of myelodysplastic syndrome, from whom Burkholderia cepacia was isolated in blood culture, after the 2(nd) cycle of induction. She was sensitive to ceftazidime, but its eradication was not easy. Five other patients were contaminated with this bacteria, but all of them had favourable evolution. The case is discussed in the context of those similar in literature.

摘要

血液恶性肿瘤患者易发生不常见细菌感染,如伯克霍尔德菌属,该菌通常对许多抗生素和防腐剂具有耐药性。我们报告了一例 2 型急性髓系白血病伴骨髓增生异常综合征患者的病例,该患者在诱导第 2 周期后从血培养中分离出伯克霍尔德菌属。她对头孢他啶敏感,但清除并不容易。另外 5 名患者也被这种细菌污染,但他们的病情均有好转。本文结合文献中类似的病例进行了讨论。

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Burkholderia cepacia septicemia in a patient with acute myeloid leukemia in postchemotherapy bone marrow aplasia.化疗后骨髓再生不良的急性髓系白血病患者并发洋葱伯克霍尔德菌败血症。
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本文引用的文献

1
An outbreak of Burkholderia cepacia bacteremia in hospitalized hematology patients selectively affecting those with acute myeloid leukemia.住院血液科患者中洋葱伯克霍尔德菌菌血症的爆发,选择性地影响急性髓系白血病患者。
Am J Infect Control. 2013 Apr;41(4):312-6. doi: 10.1016/j.ajic.2012.04.325. Epub 2012 Oct 4.
2
Peculiarities of cell death mechanisms in neutrophils.中性粒细胞细胞死亡机制的特点。
Cell Death Differ. 2011 Sep;18(9):1457-69. doi: 10.1038/cdd.2011.75. Epub 2011 Jun 3.
3
Antisense phosphorodiamidate morpholino oligomers targeted to an essential gene inhibit Burkholderia cepacia complex.反义磷酸二酰胺吗啉寡聚物靶向必需基因抑制伯克霍尔德菌复合群。
J Infect Dis. 2010 Jun 15;201(12):1822-30. doi: 10.1086/652807.
4
Plant-associated bacterial degradation of toxic organic compounds in soil.植物相关细菌对土壤中有毒有机化合物的降解
Int J Environ Res Public Health. 2009 Aug;6(8):2226-47. doi: 10.3390/ijerph6082226. Epub 2009 Aug 12.
5
Identification of Burkholderia cepacia complex bacteria with a lipopolysaccharide-specific monoclonal antibody.用脂多糖特异性单克隆抗体鉴定洋葱伯克霍尔德氏菌复合菌。
J Med Microbiol. 2010 Jan;59(Pt 1):41-47. doi: 10.1099/jmm.0.012500-0.
6
Species distribution and antimicrobial susceptibility of gram-negative aerobic bacteria in hospitalized cancer patients.住院癌症患者中革兰氏阴性需氧菌的菌种分布及抗菌药物敏感性
J Transl Med. 2009 Feb 19;7:14. doi: 10.1186/1479-5876-7-14.
7
Biocide susceptibility of the Burkholderia cepacia complex.洋葱伯克霍尔德菌复合体的杀生物剂敏感性
J Antimicrob Chemother. 2009 Mar;63(3):502-10. doi: 10.1093/jac/dkn540. Epub 2009 Jan 18.
8
Moisturizing body milk as a reservoir of Burkholderia cepacia: outbreak of nosocomial infection in a multidisciplinary intensive care unit.作为洋葱伯克霍尔德菌储存源的保湿身体乳:多学科重症监护病房的医院感染暴发
Crit Care. 2008;12(1):R10. doi: 10.1186/cc6778. Epub 2008 Jan 31.
9
Persistent bacteraemia caused by a single clone of Burkholderia cepacia with unusual phenotype.由具有异常表型的洋葱伯克霍尔德菌单一克隆引起的持续性菌血症。
J Infect. 2001 Apr;42(3):202-5. doi: 10.1053/jinf.2001.0825.
10
[Nosocomial respiratory infection caused by Pseudomonas cepacia in immunocompromised hosts].[免疫功能低下宿主中洋葱伯克霍尔德菌引起的医院获得性呼吸道感染]
Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Jul;30(7):1215-21.