Shu-hui Wang, Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Yong-bo Zhang, Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Pak J Med Sci. 2013 Sep;29(5):1288-9. doi: 10.12669/pjms.295.3793.
Miller Fisher's syndrome (MFS) commonly presents in the fourth and fifth decades and are rare in people over 70 years. An 85-year-old female with no significant medical history presented with upper extremity anesthesia, ptosis, and unsteady gait. The patient had a history of hypertension and diabetes mellitus. Physical examination showed bilateral total external ophthalmoplegia, areflexia, and cerebellar ataxia. Radiological and laboratory studies were unremarkable. Lumbar puncture showed albuminocytological dissociation. The combined history, physical examination, and lumbar puncture results established a presumptive diagnosis of MFS. Intravenous immunoglobulin was given for 5 days. The patient gradually improved 10 days after the onset of symptoms. Ophthalmoplegia had fully recovered after 6 months. To the best of our knowledge, this case represented the oldest patient with MFS.
米勒费舍尔综合征（MFS）常见于第四和第五个十年，在 70 岁以上的人群中较为罕见。一位 85 岁女性，无明显病史，表现为上肢感觉异常、上睑下垂和步态不稳。患者有高血压和糖尿病病史。体格检查显示双侧完全性眼外肌瘫痪、反射消失和小脑共济失调。影像学和实验室研究未见异常。腰椎穿刺显示蛋白细胞分离。综合病史、体格检查和腰椎穿刺结果，初步诊断为 MFS。给予静脉注射免疫球蛋白 5 天。症状发作后 10 天，患者逐渐好转。6 个月后眼肌瘫痪完全恢复。据我们所知，该病例是 MFS 患者中年龄最大的。
