Nakanishi Katsuyuki, Osuga Keigo, Hori Shinichi, Hamada Kenichiro, Hashimoto Nobuyuki, Araki Nobuhito, Yoshikawa Hideki, Tomiyama Noriyuki
Department of Diagnostic Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3, Nakamichi, Higashinari-ku Osaka, 537-8511 Japan.
Department of Diagnostic and Interventional Radiology Osaka University Graduate School of Medicine, Osaka, Japan.
Springerplus. 2013 Dec 11;2:666. doi: 10.1186/2193-1801-2-666. eCollection 2013.
We retrospectively evaluated our experience of transcatheter arterial embolization (TAE) of the sacral GCT with use of a spherical permanent embolic agent, superabsorbant polymer microsphere (SAP-MS) as an alternative treatment modality.
From 1997 to 2011, four patients with sacral GCT were treated with TAE. In all cases, SAP-MS was used as an embolic material. The effects of TAE were evaluated for improvement of patients' symptoms, radiographic change such as vascularity of tumor, size of tumor and occurrence of reossification.
Of the four patients, three responded favorably to TAE with improvement in pain and neurologic symptoms with long-term follow up. Diminished vascularity, stabilization of tumor size and reossification were shown radiographically. One patient died because of tumor growth 26 months after the initial TAE.
In sacral GCT, TAE using SAP-MS might be useful for symptom improvement, reossification of the lesion and stabilization of tumor size.
我们回顾性评估了使用球形永久性栓塞剂超吸收性聚合物微球(SAP-MS)经导管动脉栓塞术(TAE)治疗骶骨骨巨细胞瘤(GCT)作为一种替代治疗方式的经验。
1997年至2011年,4例骶骨GCT患者接受了TAE治疗。所有病例均使用SAP-MS作为栓塞材料。通过患者症状改善情况、影像学变化如肿瘤血管、肿瘤大小及再骨化情况来评估TAE的效果。
4例患者中,3例对TAE反应良好,长期随访显示疼痛和神经症状改善。影像学显示血管减少、肿瘤大小稳定及再骨化。1例患者在初次TAE后26个月因肿瘤进展死亡。
在骶骨GCT中,使用SAP-MS的TAE可能有助于改善症状、病变再骨化及稳定肿瘤大小。