Abdul Jalil Mohd Azri, Shuid Ahmad Nazrun, Muhammad Norliza
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
Curr Drug Targets. 2013 Dec;14(14):1651-8. doi: 10.2174/1389450114666131217113759.
With improvements in living standards and healthcare, life expectancy has been increasing dramatically in most parts of the world. These situations lead to the increase in the reported cases of geriatrics-related diseases such as hypogonadal osteoporosis with skeletal fracture being the ultimate outcome, which eventually causes significant morbidity and mortality. The deficient gonadal hormones, which are the main cause of hypogonadal osteoporosis, could be substituted with hormone replacement therapy to hinder bone loss. However, the artificial hormonal therapy has been linked to grievous conditions such as breast and prostate cancers. In view of the various adverse effects associated with conventional treatment, many researchers are now focusing on finding alternative remedies from nature. This article explores the possibilities of certain medicinal plants native to Malaysia that possess androgenic and antioxidant properties to potentially be used in the treatment of fracture due to osteoporosis in ageing people.
随着生活水平和医疗保健的改善,世界上大多数地区的预期寿命一直在急剧增加。这些情况导致与老年病相关疾病的报告病例增加,例如性腺功能减退性骨质疏松症,最终结果是骨骼骨折,这最终会导致显著的发病率和死亡率。性腺激素缺乏是性腺功能减退性骨质疏松症的主要原因,可以通过激素替代疗法来替代,以阻止骨质流失。然而,人工激素疗法与诸如乳腺癌和前列腺癌等严重疾病有关。鉴于传统治疗存在的各种不良反应,许多研究人员现在正专注于从天然物质中寻找替代疗法。本文探讨了马来西亚本土某些具有雄激素和抗氧化特性的药用植物用于治疗老年人骨质疏松性骨折的可能性。