Morimoto K, Kitamura M, Kondo H, Koizumi A
Dev Toxicol Environ Sci. 1986;13:85-101.
The present studies confirm that diesel exhaust emissions are mutagenic in bacterial and mammalian mutation assays. Our results further indicate that mutagenic potential of the diesel tar samples can be reduced by exogenous metabolic activation with S15, and that Epstein-Barr-virus transformed lymphoblastoid cell lines from Bloom syndrome, and Xeroderma Pigmentosum patients with a high incidence of malignant tumors showed an larger production of SCEs while those from Fanconi anemia patients had an lower frequency of SCEs when exposed to the diesel emission condensate, compared to those from normal healthy persons. On the contrary to the results of in-vitro studies, the in-vivo SCE and micronucleus assays using mouse and rat bone marrow cells gave negative responses.
目前的研究证实，柴油机废气排放物在细菌和哺乳动物突变试验中具有致突变性。我们的结果进一步表明，柴油焦油样品的致突变潜力可通过用S15进行外源性代谢活化来降低，而且来自布鲁姆综合征患者以及恶性肿瘤发病率高的着色性干皮病患者的爱泼斯坦-巴尔病毒转化淋巴母细胞系，在暴露于柴油机排放冷凝物时，与正常健康人的细胞系相比，显示出更高的姐妹染色单体交换（SCE）发生率，而范可尼贫血患者的细胞系SCE频率较低。与体外研究结果相反，使用小鼠和大鼠骨髓细胞进行的体内SCE和微核试验给出了阴性反应。
