Gottlob I, Schneider E, Heider W, Skrandies W
Electroencephalogr Clin Neurophysiol. 1987 Apr;66(4):349-57. doi: 10.1016/0013-4694(87)90032-0.
A group of 24 patients with Parkinson's disease (PD) with normal fundi and normal visual acuities was examined electrophysiologically. Checkerboard reversal VEPs and ERGs (P-ERGs) at various contrast levels as well as photopic and scotopic luminance ERGs were recorded and compared with an age-matched group of controls. Earlier reported latency increases of the VEPs of the patients were confirmed for patterns of high contrast only. Scotopic and photopic luminance ERGs of the patients showed normal latencies, but at all light intensities the amplitudes of the scotopic and photopic b wave, as well as the amplitudes of the photopic a waves, were significantly reduced, P-ERG amplitudes were reduced at 50% contrast. Identical results were obtained in patients under dopaminergic treatment (n = 17) and in patients who did not receive any treatment (n = 7). These results suggest that alterations occur already at the retinal level where dopamine receptors have been found. Thus the reported changes of the VEP are not caused by the visual cortex alone.
对24名眼底正常且视力正常的帕金森病（PD）患者进行了电生理检查。记录了不同对比度水平下的棋盘格翻转视觉诱发电位（VEP）和视网膜电图（ERG，P-ERG）以及明视和暗视亮度ERG，并与年龄匹配的对照组进行比较。先前报道的患者VEP潜伏期增加仅在高对比度模式下得到证实。患者的暗视和明视亮度ERG潜伏期正常，但在所有光强度下，暗视和明视b波的振幅以及明视a波的振幅均显著降低，P-ERG振幅在50%对比度时降低。在接受多巴胺能治疗的患者（n = 17）和未接受任何治疗的患者（n = 7）中获得了相同的结果。这些结果表明，在已发现多巴胺受体的视网膜水平就已经出现了改变。因此，所报道的VEP变化并非仅由视觉皮层引起。
