Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Arch Phys Med Rehabil. 2014 Apr;95(4):726-33. doi: 10.1016/j.apmr.2013.11.018. Epub 2013 Dec 16.
To assess whether sensorimotor peripheral nerve function is associated with muscle power in community-dwelling older men.
Longitudinal cohort study with 2.3±0.3 years of follow-up.
One clinical site.
Participants (n=372; mean age ± SD, 77.2±5.1y; 99.5% white; body mass index, 27.9±3.7kg/m(2); power, 1.88±0.6W/kg) at 1 site of the Osteoporotic Fractures in Men Study (N=5994).
Not applicable.
A nerve function ancillary study was performed 4.6±0.4 years after baseline. Muscle power was measured using a power rig. Peroneal motor nerve conduction amplitude, distal motor latency, and mean f-wave latency were measured. Sensory nerve function was assessed using 10-g and 1.4-g monofilaments and sural sensory nerve conduction amplitude and distal latency. Peripheral neuropathy symptoms at the leg and feet were assessed by self-report.
After adjustments for age, height, and total body lean and fat mass, 1 SD lower motor (β=-.07, P<.05) and sensory amplitude (β=-.09, P<.05) and 1.4-g (β=-.11, P<.05) and 10-g monofilament insensitivity (β=-.17, P<.05) were associated with lower muscle power/kg. Compared with the effect of age on muscle power (β per year, -.05; P<.001), this was equivalent to aging 1.4 years for motor amplitude, 1.8 years for sensory amplitude, 2.2 years for 1.4-g monofilament detection, and 3.4 years for 10-g detection. Baseline 1.4-g monofilament detection predicted a greater decline in muscle power/kg. Short-term change in nerve function was not associated with concurrent short-term change in muscle power/kg.
Worse sensory and motor nerve function were associated with lower muscle power/kg and are likely important for impaired muscle function in older men. Monofilament sensitivity was associated with a greater decline in muscle power/kg, and screening may identify an early risk for muscle function decline in late life, which has implications for disability.
评估社区居住的老年男性感觉运动周围神经功能与肌肉力量之间的关系。
随访 2.3±0.3 年的纵向队列研究。
一个临床地点。
男性骨质疏松性骨折研究（N=5994）中 1 个部位的参与者（n=372；平均年龄±标准差，77.2±5.1y；99.5%为白人；体重指数，27.9±3.7kg/m(2)；力量，1.88±0.6W/kg）。
不适用。
基线后 4.6±0.4 年进行神经功能辅助研究。肌肉力量使用力量测试装置进行测量。测量腓总运动神经传导幅度、远端运动潜伏期和平均 f 波潜伏期。使用 10g 和 1.4g 单丝评估感觉神经功能和腓肠感觉神经传导幅度和远端潜伏期。通过自我报告评估腿部和脚部的周围神经病变症状。
调整年龄、身高以及全身瘦体重和脂肪量后，1 个标准差较低的运动（β=-.07，P<.05）和感觉幅度（β=-.09，P<.05）以及 1.4-g（β=-.11，P<.05）和 10-g 单丝感觉迟钝（β=-.17，P<.05）与较低的肌肉力量/体重有关。与年龄对肌肉力量的影响（β/年，-.05；P<.001）相比，运动幅度相当于老化 1.4 年，感觉幅度老化 1.8 年，1.4-g 单丝检测老化 2.2 年，10-g 检测老化 3.4 年。基线时 1.4-g 单丝检测可预测肌肉力量/体重的更大下降。神经功能的短期变化与同期肌肉力量/体重的短期变化无关。
感觉和运动神经功能较差与较低的肌肉力量/体重有关，这可能对老年男性肌肉功能受损很重要。单丝敏感度与肌肉力量/体重的下降幅度更大有关，筛查可能会识别晚年肌肉功能下降的早期风险，这对残疾有影响。
