Cantatore P, Flagella Z, Fracasso F, Lezza A M, Gadaleta M N, de Montalvo A
FEBS Lett. 1987 Mar 9;213(1):144-8. doi: 10.1016/0014-5793(87)81480-1.
The synthesis and turnover rates of the two 12 S and 16 S mt rRNAs and of the mt mRNAs for subunits I and III of cytochrome oxidase have been determined by measuring the kinetics of incorporation of [3H]uridine in the mtRNA of rat hepatocytes. All the RNA species examined have approximately the same turnover (t1/2 approximately 100 min) and therefore the rate of synthesis, which is about 10-times higher for the rRNAs, seems to be the factor responsible for the different mt rRNA and mRNA steady-state levels.
通过测量[3H]尿苷掺入大鼠肝细胞线粒体RNA的动力学，已确定了两种12S和16S线粒体rRNA以及细胞色素氧化酶亚基I和III的线粒体mRNA的合成和周转率。所有检测的RNA种类都具有大致相同的周转率（半衰期约100分钟），因此，rRNA合成速率约高10倍，这似乎是造成线粒体rRNA和mRNA稳态水平不同的因素。
