[铁调素作为与肥胖相关的慢性疾病贫血的核心介质]

[Hepcidin as a central mediator of anemia of chronic diseases associated with obesity].

作者信息

Villarroel H Pía, Arredondo O Miguel, Olivares G Manuel

机构信息

Laboratorio de Micronutriente, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile,

出版信息

Rev Med Chil. 2013 Jul;141(7):887-94. doi: 10.4067/S0034-98872013000700008.

DOI:10.4067/S0034-98872013000700008

PMID:24356737

Abstract

Recent evidence suggests that obesity-related inflammation may play a central role in hepcidin regulation. Hepcidin is a key regulator ofiron homeostasis and has now been suggested as a central mediator ofiron metabolism disorders involved in the pathogenesis of anemia of chronic disease. In this review, we focus on subclinical inflammation in obesity and its effect on hepcidin levels, as the most plausible explanation for the relationship between anemia of chronic disease and obesity.

摘要

最近的证据表明，肥胖相关炎症可能在铁调素调节中起核心作用。铁调素是铁稳态的关键调节因子，目前已被认为是参与慢性病贫血发病机制的铁代谢紊乱的主要介质。在本综述中，我们关注肥胖中的亚临床炎症及其对铁调素水平的影响，这是慢性病贫血与肥胖之间关系最合理的解释。