Chang Jung-Su, Li Yu-Ling, Lu Chiou-Han, Owaga Eddy, Chen Wei-Yu, Chiou Hung-Yi
School of Nutrition and Health Sciences, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan, Republic of China.
School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan, Republic of China.
Nutrition. 2014 Oct;30(10):1165-70. doi: 10.1016/j.nut.2014.02.021. Epub 2014 Mar 12.
A sharp increase in the prevalence of obesity and a decline in iron deficiency in children was observed between the two consecutive Nutrition and Health Surveys in Taiwan. The aim of this study was to evaluate the distribution of hepcidin in relation to nutritional status in children.
648 children ages 7 to 13 y living in Taipei and New Taipei City were enrolled in this study. Parameters for obesity, iron status, and inflammatory markers were evaluated.
There were no differences in the prevalence of iron deficiency and iron depletion between normal and overweight/obese children. A V-sharp hepcidin distribution curve was seen in normal weight children and overweight/obese boys. Serum hepcidin levels remained stable in overweight/obese girls during transition from childhood to teenager. Overweight/obese children had increased serum nitric oxide (NO) and interleukin (IL)-1β but decreased IL-10 concentration compared with normal weight children. A strong inverse relationship was found between IL-10 and body mass index (BMI; odds ratio (OR), 0.86, 95% confidence interval [CI], 0.83-0.89). By contrast, positive correlations were observed between BMI and IL-1β (OR, 1.60; 95% CI, 1.29-1.98); and between BMI and NO (OR, 1.04, 95% CI, 1.02-1.07). Multivariate linear regression analysis showed serum hepcidin was significantly correlated with IL-10 (β = 0.26, P < 0.0001).
Our results raise the possibility that IL-10 may play a role in iron homeostasis. Decreased circulating IL-10 concentration may temporary protect young overweight/obese girls against the development of iron deficiency. However, long-term decrease in hepcidin concentration may increase the risk for iron overload in overweight/obese children.
在台湾连续两次营养与健康调查之间，观察到儿童肥胖患病率急剧上升，缺铁情况有所下降。本研究的目的是评估儿童中与营养状况相关的铁调素分布情况。
本研究纳入了648名居住在台北和新北市的7至13岁儿童。评估了肥胖、铁状态和炎症标志物的参数。
正常体重儿童与超重/肥胖儿童在缺铁和铁耗竭患病率方面没有差异。在正常体重儿童和超重/肥胖男孩中观察到铁调素呈V形分布曲线。超重/肥胖女孩从儿童期过渡到青少年期时，血清铁调素水平保持稳定。与正常体重儿童相比，超重/肥胖儿童的血清一氧化氮（NO）和白细胞介素（IL）-1β增加，但IL-10浓度降低。发现IL-10与体重指数（BMI；优势比（OR），0.86，95%置信区间[CI]，0.83 - 0.89）之间存在强烈的负相关。相比之下，观察到BMI与IL-1β之间存在正相关（OR，1.60；95%CI，1.29 - 1.98）；以及BMI与NO之间存在正相关（OR，1.04，95%CI，1.02 - 1.07）。多变量线性回归分析显示血清铁调素与IL-10显著相关（β = 0.26，P < 0.0001）。
我们的结果提出了IL-10可能在铁稳态中起作用的可能性。循环中IL-10浓度降低可能暂时保护年轻超重/肥胖女孩免于缺铁的发展。然而，铁调素浓度的长期降低可能会增加超重/肥胖儿童铁过载的风险。
