Laboratory of Biophysics, Department of Medical Research, Taipei Veterans General Hospital, Taipei, 112, Taiwan.
J Clin Monit Comput. 2014 Aug;28(4):387-401. doi: 10.1007/s10877-013-9545-3. Epub 2013 Dec 20.
The Poincaré plot of RR intervals (RRI) is obtained by plotting RRIn+1 against RRIn. The Pearson correlation coefficient (ρRRI), slope (SRRI), Y-intercept (YRRI), standard deviation of instantaneous beat-to-beat RRI variability (SD1RR), and standard deviation of continuous long-term RRI variability (SD2RR) can be defined to characterize the plot. Similarly, the Poincaré plot of autocorrelation function (ACF) of RRI can be obtained by plotting ACFk+1 against ACFk. The corresponding Pearson correlation coefficient (ρACF), slope (SACF), Y-intercept (YACF), SD1ACF, and SD2ACF can be defined similarly to characterize the plot. By comparing the indices of Poincaré plots of RRI and ACF between patients with acute myocardial infarction (AMI) and patients with patent coronary artery (PCA), we found that the ρACF and SACF were significantly larger, whereas the RMSSDACF/SDACF and SD1ACF/SD2ACF were significantly smaller in AMI patients. The ρACF and SACF correlated significantly and negatively with normalized high-frequency power (nHFP), and significantly and positively with normalized very low-frequency power (nVLFP) of heart rate variability in both groups of patients. On the contrary, the RMSSDACF/SDACF and SD1ACF/SD2ACF correlated significantly and positively with nHFP, and significantly and negatively with nVLFP and low-/high-frequency power ratio (LHR) in both groups of patients. We concluded that the ρACF, SACF, RMSSDACF/SDACF, and SD1ACF/SD2ACF, among many other indices of ACF Poincaré plot, can be used to differentiate between patients with AMI and patients with PCA, and that the increase in ρACF and SACF and the decrease in RMSSDACF/SDACF and SD1ACF/SD2ACF suggest an increased sympathetic and decreased vagal modulations in both groups of patients.
RR 间期的 Poincaré 图通过绘制 RRIn+1 与 RRIn 来获得。可以定义 Pearson 相关系数 (ρRRI)、斜率 (SRRI)、Y 截距 (YRRI)、即时逐搏 RR 间期变异性的标准差 (SD1RR) 和连续长期 RR 间期变异性的标准差 (SD2RR)，以描述该图。同样，可以通过绘制 ACFk+1 与 ACFk 来获得 RR 间期自相关函数 (ACF)的 Poincaré 图。可以类似地定义相应的 Pearson 相关系数 (ρACF)、斜率 (SACF)、Y 截距 (YACF)、SD1ACF 和 SD2ACF，以描述该图。通过比较急性心肌梗死 (AMI) 患者和冠状动脉通畅 (PCA) 患者的 RR 间期和 ACF 的 Poincaré 图指标，我们发现 AMI 患者的 ρACF 和 SACF 显著增大，而 RMSSDACF/SDACF 和 SD1ACF/SD2ACF 显著减小。ρACF 和 SACF 与两组患者的心率变异性的归一化高频功率 (nHFP) 显著负相关，与归一化极低频功率 (nVLFP) 显著正相关。相反，RMSSDACF/SDACF 和 SD1ACF/SD2ACF 与两组患者的 nHFP 显著正相关，与 nVLFP 和低/高频功率比 (LHR) 显著负相关。我们得出结论，ACF Poincaré 图的许多其他指标，如 ρACF、SACF、RMSSDACF/SDACF 和 SD1ACF/SD2ACF，可用于区分 AMI 患者和 PCA 患者，并且 ρACF 和 SACF 的增加以及 RMSSDACF/SDACF 和 SD1ACF/SD2ACF 的减少表明两组患者的交感神经活动增加和迷走神经活动减少。
