Rojas-Ríos Patricia, González-Reyes Acaimo
Centro Andaluz de Biología del Desarrollo, CSIC/Universidad Pablo de Olavide/JA, Carretera de Utrera km 1, Sevilla, Spain.
Stem Cells. 2014 Apr;32(4):852-9. doi: 10.1002/stem.1621.
Stem cell activity is tightly regulated during development and in adult tissues through the combined action of local and systemic effectors. While stem cells and their microenvironments are capable of sustaining homeostasis in normal physiological circumstances, they also provide host tissues with a remarkable plasticity to respond to perturbations. Here, we review recent discoveries that shed light on the adaptive response of niches to systemic signals and aging, and on the ability of niches to modulate signaling upon local perturbations. These characteristics of stem cells and their niches give organs an essential advantage to deal with aging, injury or pathological conditions.
在发育过程中和成体组织中，干细胞活性通过局部和全身效应器的联合作用受到严格调控。虽然干细胞及其微环境在正常生理情况下能够维持体内平衡，但它们也为宿主组织提供了显著的可塑性，以应对干扰。在这里，我们回顾了最近的发现，这些发现揭示了生态位对全身信号和衰老的适应性反应，以及生态位在局部干扰时调节信号传导的能力。干细胞及其生态位的这些特性赋予器官应对衰老、损伤或病理状况的重要优势。
