Zhu Ye, Akagi Takami, Akashi Mitsuru
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Macromol Biosci. 2014 Apr;14(4):576-87. doi: 10.1002/mabi.201300434. Epub 2013 Dec 19.
Amphiphilic graft copolymers, poly(γ-glutamic acid)-graft-poly(lactide) (γ-PGA-g-PLA) bearing pendent poly(L-lactide) (PLLA) or poly(D-lactide) (PDLA) of different main chain lengths and grafting degrees, self-assemble in aqueous solution to form monodispersed stereocomplex nanoparticles (NPs). The mean diameter and degree of crystallinity of these stereocomplex NPs can be controlled by changing the grafting degree of the copolymers or the preparation methods. Moreover, the stereocomplex NPs exhibit a lower critical aggregation concentration as well as stronger thermodynamic stability compared with the corresponding isomer NPs. The surface-functionalized ability and protein encapsulation capacity of the stereocomplex NPs as potential targeting protein carriers are evaluated. Furthermore, these stereocomplex NPs have strong kinetic stability and can be expected to serve as stable delivery vehicles for pharmaceutical and biomedical applications.
两亲性接枝共聚物，即带有不同主链长度和接枝度的侧链聚（L-丙交酯）（PLLA）或聚（D-丙交酯）（PDLA）的聚（γ-谷氨酸）-接枝-聚（丙交酯）（γ-PGA-g-PLA），在水溶液中自组装形成单分散的立体复合纳米颗粒（NPs）。这些立体复合纳米颗粒的平均直径和结晶度可以通过改变共聚物的接枝度或制备方法来控制。此外，与相应的异构体纳米颗粒相比，立体复合纳米颗粒表现出更低的临界聚集浓度以及更强的热力学稳定性。评估了立体复合纳米颗粒作为潜在靶向蛋白载体的表面功能化能力和蛋白质包封能力。此外，这些立体复合纳米颗粒具有很强的动力学稳定性，有望作为药物和生物医学应用的稳定递送载体。
