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In systemic sclerosis patients, bosentan is safe and effective for digital ulcer prevention and it seems to attenuate the development of pulmonary arterial hypertension.

作者信息

Romaniello Antonella, Viola Giovanna, Salsano Felice, Rosato Edoardo

机构信息

Sapienza Department of Clinical Medicine, Clinical Immunology Unit, University of Rome, Viale dell'Università 37, 00185 Rome, Italy.

出版信息

Rheumatology (Oxford). 2014 Mar;53(3):570-1. doi: 10.1093/rheumatology/ket424. Epub 2013 Dec 18.

DOI:10.1093/rheumatology/ket424
PMID:24357809
Abstract
摘要

相似文献

1
In systemic sclerosis patients, bosentan is safe and effective for digital ulcer prevention and it seems to attenuate the development of pulmonary arterial hypertension.在系统性硬化症患者中，波生坦对于预防指端溃疡是安全有效的，并且似乎可以减缓肺动脉高压的发展。
Rheumatology (Oxford). 2014 Mar;53(3):570-1. doi: 10.1093/rheumatology/ket424. Epub 2013 Dec 18.
2
New hope for systemic sclerosis patients with digital ulcers.患有指端溃疡的系统性硬化症患者迎来新希望。
Curr Rheumatol Rep. 2005 Apr;7(2):127-8. doi: 10.1007/s11926-005-0064-1.
3
Successful treatment of systemic sclerosis digital ulcers and pulmonary arterial hypertension with endothelin receptor antagonist bosentan.使用内皮素受体拮抗剂波生坦成功治疗系统性硬化症指端溃疡和肺动脉高压。
Rheumatology (Oxford). 2003 Jan;42(1):191-3. doi: 10.1093/rheumatology/keg050.
4
Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist.系统性硬化症中的指端溃疡：通过口服内皮素受体拮抗剂波生坦治疗进行预防
Arthritis Rheum. 2004 Dec;50(12):3985-93. doi: 10.1002/art.20676.
5
Bosentan: a review of its use in the management of digital ulcers associated with systemic sclerosis.波生坦：用于治疗系统性硬化症相关指端溃疡的综述
Drugs. 2009 Oct 1;69(14):2005-24. doi: 10.2165/10489160-000000000-00000.
6
Liver impairment after concomitant administration of bosentan and clarithromycin in systemic sclerosis.系统性硬化症患者同时服用波生坦和克拉霉素后出现肝功能损害。
Joint Bone Spine. 2010 Jan;77(1):81-2. doi: 10.1016/j.jbspin.2009.04.010. Epub 2009 Dec 22.
7
Bosentan for digital ulcers in patients with systemic sclerosis: a prospective 3-year followup study.波生坦治疗系统性硬化症患者指端溃疡：一项为期3年的前瞻性随访研究。
J Rheumatol. 2009 Jul;36(7):1550-2. doi: 10.3899/jrheum.080992.
8
Bosentan for digital ulcers prevention does not worsen cardiopulmonary exercise test parameters in SSc patients with interstitial lung disease.在患有间质性肺病的系统性硬化症患者中，波生坦用于预防指端溃疡不会使心肺运动试验参数恶化。
Int J Cardiol. 2016 Nov 15;223:113-115. doi: 10.1016/j.ijcard.2016.08.095. Epub 2016 Aug 6.
9
A higher degree of criticism about the effectiveness of bosentan for digital ulcers in scleroderma patients, as for interstitial disease, is also necessary: comment on the article by Seibold et al.对于波生坦治疗硬皮病患者指端溃疡的有效性，如同其治疗间质性疾病一样，也需要更高程度的批判性审视：对Seibold等人文章的评论
Arthritis Rheum. 2010 Oct;62(10):3128-9; author reply 3129-30. doi: 10.1002/art.27637.
10
Bosentan as a rescue therapy in scleroderma refractory digital ulcers.波生坦作为硬皮病难治性指端溃疡的挽救治疗方法。
Arch Dermatol. 2007 Jan;143(1):125-6. doi: 10.1001/archderm.143.1.125.

引用本文的文献

1
Effect of bosentan in pulmonary hypertension development in systemic sclerosis patients with digital ulcers.波生坦治疗系统性硬皮病伴指端溃疡患者肺动脉高压的疗效。
PLoS One. 2020 Dec 10;15(12):e0243651. doi: 10.1371/journal.pone.0243651. eCollection 2020.
2
Is macitentan not a treatment option for digital ulcers in systemic sclerosis?马昔腾坦难道不是系统性硬化症中治疗指端溃疡的一种选择吗？
Ann Transl Med. 2016 Oct;4(Suppl 1):S6. doi: 10.21037/atm.2016.08.67.
3
D-optimal Design for Preparation and Optimization of Fast Dissolving Bosentan Nanosuspension.
快速溶解波生坦纳米混悬液制备与优化的D-最优设计
Adv Pharm Bull. 2016 Jun;6(2):211-8. doi: 10.15171/apb.2016.029. Epub 2016 Jun 30.