N-丙酰化B群脑膜炎球菌多糖模拟B群脑膜炎奈瑟菌上的一个独特表位。
N-propionylated group B meningococcal polysaccharide mimics a unique epitope on group B Neisseria meningitidis.
作者信息
Jennings H J, Gamian A, Ashton F E
出版信息
J Exp Med. 1987 Apr 1;165(4):1207-11. doi: 10.1084/jem.165.4.1207.
Abstract
Antibodies induced in mice by the N-propionyl (N-Pr)-group B meningococcal polysaccharide (GBMP)-tetanus toxoid (TT) conjugate were bactericidal for GBM organisms independent of protein serotype. The antisera contained two populations of N-Pr-GBMP-specific antibodies, only one of which crossreacted with the GBMP. Particularly significant was the fact that the bactericidal activity was mainly associated with the population of antibodies that did not crossreact with the GBMP. Therefore it can be inferred from the above evidence that the N-Pr-GBMP mimics a unique epitope on the surface of GBM organisms that is not present on the exogenous GBMP.
摘要
由N-丙酰基（N-Pr）-B群脑膜炎球菌多糖（GBMP）-破伤风类毒素（TT）结合物在小鼠体内诱导产生的抗体对GBM菌株具有杀菌作用，且与蛋白质血清型无关。抗血清中含有两类N-Pr-GBMP特异性抗体，其中只有一类与GBMP发生交叉反应。特别重要的是，杀菌活性主要与不与GBMP发生交叉反应的那类抗体相关。因此，从上述证据可以推断，N-Pr-GBMP模拟了GBM菌株表面一种在外源GBMP上不存在的独特表位。
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