Urology. 2013 Nov;82(5):1175-8. doi: 10.1016/j.urology.2013.06.051.
To determine the appropriate resection margin, we performed photodynamic diagnosis (PDD) mediated by 5-aminolevulinic acid (ALA; ALA-PDD) during robot-assisted laparoscopic radical prostatectomy (RALP).
We performed ALA-PDD during RALP using da Vinci S Surgical System in 6 patients. The function of TilePro multi-image stereo-viewer enables simultaneous 2-tiered display of the real surgical field by the da Vinci S Surgical System and the ALA-PDD endoscopic system in surgeon console. The resection margins of prostate were biopsied under the observation of ALA-PDD and assessed pathologically.
The process of ALA-PDD during RALP was proceeded favorably in all the 6 patients. All 22 biopsy specimens obtained from resection margin of prostate demonstrated fluorescence-negative inside the body and also pathologically confirmed negative findings in malignancy. Moreover, no perioperative complications were observed through all procedures of ALA-PDD in all the 6 patients.
We presented particularly that application of ALA-PDD during RALP, as a novel and practical technique for decision of the correct resection margin.
为了确定合适的切除边缘，我们在机器人辅助腹腔镜前列腺切除术（RALP）期间进行了 5-氨基酮戊酸（ALA；ALA-PDD）介导的光动力诊断（PDD）。
我们在 6 名患者的 RALP 中使用达芬奇 S 手术系统进行了 ALA-PDD。TilePro 多图像立体查看器的功能使达芬奇 S 手术系统和 ALA-PDD 内窥镜系统在手术控制台中能够同时显示两层实时手术场。在 ALA-PDD 的观察下对前列腺的切除边缘进行活检，并进行病理评估。
在所有 6 名患者中，RALP 期间的 ALA-PDD 过程均顺利进行。从前列腺切除边缘获得的所有 22 个活检标本在体内均显示荧光阴性，并且在恶性肿瘤方面也通过病理证实为阴性发现。此外，在所有 6 名患者的 ALA-PDD 所有手术过程中均未观察到围手术期并发症。
我们特别提出，在 RALP 期间应用 ALA-PDD 作为一种新的实用技术，可以确定正确的切除边缘。
