Hervás Ontiveros A, Salom D, España Gregori E, Jiménez Herrero E, Díaz-Llopis M
Servicio de Oftalmología, Hospital Universitario la Fe, Valencia, España.
Servicio de Oftalmología, Hospital Universitario la Fe, Valencia, España.
Arch Soc Esp Oftalmol. 2014 Nov;89(11):447-9. doi: 10.1016/j.oftal.2013.10.009. Epub 2013 Dec 19.
A 73 year-old woman presented with a history of non-specific symptoms and photophobia in both eyes of 1 year progression. The examination revealed a bilateral symblepharon and fornix shortening. Immunohistochemical analysis confirmed the presence of linear deposits of IgG, IgM and C3 along the conjunctival basement membrane. With the diagnosis of Ocular Cicatricial Pemphigoid, systemic treatment with subcutaneous methotrexate was prescribed.
We consider such treatment a very effective initial immunosuppressive alternative in patients with moderate conjunctival inflammation and in cases of rapid progression.
一名73岁女性，有非特异性症状病史，双眼畏光1年且病情进展。检查发现双侧睑球粘连和穹窿缩短。免疫组织化学分析证实沿结膜基底膜有IgG、IgM和C3的线性沉积。诊断为瘢痕性类天疱疮性睑球粘连，给予皮下注射甲氨蝶呤进行全身治疗。
我们认为这种治疗方法对于中度结膜炎症且病情快速进展的患者是一种非常有效的初始免疫抑制替代方案。
