西班牙EPIC队列研究中总ω-3脂肪酸、二十碳五烯酸和二十二碳六烯酸的摄入量与冠心病风险

Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study.

作者信息

Amiano P, Machón M, Dorronsoro M, Chirlaque M Dolores, Barricarte A, Sánchez M-J, Navarro C, Huerta J M, Molina-Montes E, Sánchez-Cantalejo E, Urtizberea M, Arriola L, Larrañaga N, Ardanaz E, Quirós J R, Moreno-Iribas C, González C A

机构信息

Public Health Department of Gipuzkoa, Government of the Basque Country, and BioDonostia Research Institute, San Sebastian, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), Madrid, Spain.

Primary Care Research Unit OSIs of Gipuzkoa, Basque Health Service-Osakidetza, San Sebastian, Spain; Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Spain.

出版信息

Nutr Metab Cardiovasc Dis. 2014 Mar;24(3):321-7. doi: 10.1016/j.numecd.2013.08.011. Epub 2013 Dec 20.

DOI:10.1016/j.numecd.2013.08.011

PMID:24360762

Abstract

BACKGROUND AND AIMS

The evidence about the benefits of omega-3 fatty acid intake on coronary heart disease (CHD) is not consistent. We thus aimed to assess the relation between dietary intake of total omega-3 fatty acids (from plant and marine foods) and marine polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on the risk of CHD in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC).

METHODS AND RESULTS

The analysis included 41,091 men and women aged 20-69 years, recruited from 1992 to 1996 and followed-up until December 2004. Omega-3 fatty acid intake was estimated from a validated dietary questionnaire. Only participants with definite incident CHD event were considered as cases. Cox regression models were used to assess the association between the intake of total omega-3 fatty acids, EPA or DHA and CHD. A total of 609 participants (79% men) had a definite CHD event. Mean intakes of total omega-3 fatty acids, EPA and DHA were very similar in the cases and in the cohort, both in men and women. In the multivariate adjusted model, omega-3 fatty acids, EPA and DHA were not related to incident CHD in either men or women. The hazard ratios (HR) for omega-3 were 1.23 in men (95% CI 0.94-15.9, p = 0.20); and 0.77 in women (95% CI 0.46-1.30, p = 0.76).

CONCLUSION

In the Spanish EPIC cohort, with a relatively high intake of fish, no association was found between EPA, DHA and total omega-3 fatty acid intake and risk of CHD.

摘要

背景与目的

关于摄入ω-3脂肪酸对冠心病（CHD）有益的证据并不一致。因此，我们旨在评估在欧洲癌症与营养前瞻性调查（EPIC）西班牙队列中，膳食中总ω-3脂肪酸（来自植物和海洋食物）以及海洋多不饱和脂肪酸（PUFA）、二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的摄入量与冠心病风险之间的关系。

方法与结果

分析纳入了1992年至1996年招募的41091名年龄在20 - 69岁的男性和女性，随访至2004年12月。通过一份经过验证的膳食问卷估算ω-3脂肪酸摄入量。仅将确诊发生冠心病事件的参与者视为病例。采用Cox回归模型评估总ω-3脂肪酸、EPA或DHA摄入量与冠心病之间的关联。共有609名参与者（79%为男性）发生了确诊的冠心病事件。病例组和队列中，男性和女性的总ω-3脂肪酸、EPA和DHA的平均摄入量非常相似。在多变量调整模型中，ω-3脂肪酸、EPA和DHA与男性或女性的冠心病发病均无关联。男性中ω-3的风险比（HR）为1.23（95%CI 0.94 - 15.9，p = 0.20）；女性中为0.77（95%CI 0.46 - 1.30，p = 0.76）。