Aoki Yuta, Mizoguchi Hirokazu, Watanabe Chizuko, Sakurada Tsukasa, Sakurada Shinobu
Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
First Department of Pharmacology, Daiichi College of Pharmaceutical Sciences, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan.
Neurosci Lett. 2014 Feb 7;560:122-5. doi: 10.1016/j.neulet.2013.12.020. Epub 2013 Dec 18.
Antinociceptive effect of narcotic analgesics, fentanyl, oxycodone and methadone in inflammatory pain state was described in the von Frey filament test using the complete Freund's adjuvant (CFA)-induced mouse inflammatory pain model. After the i.pl. injection of CFA, mechanical allodynia (decrease of mechanical threshold) was observed in ipsilateral paw. The antinociceptive effect of fentanyl and oxycodone injected s.c. against mechanical allodynia in inflammatory pain state was reduced bilaterally at 1 day after CFA pretreatment. However, the antinociceptive effect of methadone injected s.c. against mechanical allodynia in inflammatory pain state was reduced unilaterally at 1 day after CFA pretreatment. Moreover, the reduction of the antinociceptive effect of methadone in ipsilateral paw on inflammatory pain state was smaller than those of fentanyl or oxycodone. In conclusion, the alternation of the antinociceptive effect of narcotic analgesics in inflammatory pain state is variable among the narcotic analgesics used.
在使用完全弗氏佐剂（CFA）诱导的小鼠炎性疼痛模型的von Frey细丝试验中，描述了麻醉性镇痛药芬太尼、羟考酮和美沙酮在炎性疼痛状态下的抗伤害感受作用。腹腔注射CFA后，在同侧爪观察到机械性异常性疼痛（机械阈值降低）。在CFA预处理后1天，皮下注射芬太尼和羟考酮对炎性疼痛状态下机械性异常性疼痛的抗伤害感受作用双侧降低。然而，在CFA预处理后1天，皮下注射美沙酮对炎性疼痛状态下机械性异常性疼痛的抗伤害感受作用单侧降低。此外，美沙酮对炎性疼痛状态下同侧爪抗伤害感受作用的降低小于芬太尼或羟考酮。总之，在所使用的麻醉性镇痛药中，麻醉性镇痛药在炎性疼痛状态下抗伤害感受作用的变化是可变的。
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