Molecular Diagnostics Research Group, National Centre for Biomedical Engineering Science, National Diagnostics Centre, National University of Ireland, Galway, Ireland,
Ir J Med Sci. 2014 Sep;183(3):477-80. doi: 10.1007/s11845-013-1056-1. Epub 2013 Dec 22.
We investigated the link between the mRNA of the procoagulant prothrombin in the placental tissue with the increased placental fibrin deposition associated with activated protein C resistance (APCR). Women with APCR were not found to produce higher levels of prothrombin transcript compared to women with a normal APC ratio. This indicates that accumulated fibrin in the placenta is not the consequence of too much production of the procoagulant prothrombin transcript, but may be associated with altered function of other haemostatic factors interacting with APC in the placenta.
我们研究了胎盘组织中促凝血酶原 mRNA 与活化蛋白 C 抵抗（APCR）相关的胎盘纤维蛋白沉积增加之间的联系。与 APC 比值正常的女性相比，APCR 女性并未发现产生更高水平的凝血酶原转录本。这表明胎盘中积累的纤维蛋白不是由于促凝血酶原转录本的产生过多所致，而是可能与其他与 APC 在胎盘相互作用的止血因子的功能改变有关。
