Andersen P T, Nielsen L K, Møller-Petersen J, Henneberg E W, Egeblad K
Thorac Cardiovasc Surg. 1987 Feb;35(1):57-60. doi: 10.1055/s-2007-1020197.
In 10 patients undergoing aortic bypass grafting with peroperative aortic cross-clamping we measured the levels of myoglobin and creatine phosphokinase. The duration of peroperative lower limb arterial clamping ranged from 50 min to 95 min. No significant increase in either serum myoglobin or in serum creatine phosphokinase was found during lower limb arterial clamping or for the first two hours after release of ischemia. Both parameters reached a maximum value at 24 hours after release of ischemia, with a median serum myoglobin concentration of 565 micrograms/l (range: 132-2688 micrograms/l) and a median serum creatine phosphokinase activity of 457 U/l (range: 190-1602 U/l). The increase in serum myoglobin and creatine phosphokinase was not associated with the duration of lower limb arterial clamping. Renal impairment was not found in these patients, as evaluated by the serum concentration of beta 2-microglobulin.
在10例行主动脉旁路移植术并术中进行主动脉交叉钳夹的患者中，我们测量了肌红蛋白和肌酸磷酸激酶的水平。术中下肢动脉钳夹时间为50分钟至95分钟。在下肢动脉钳夹期间或缺血解除后的头两小时内，血清肌红蛋白或血清肌酸磷酸激酶均未发现显著升高。两个参数均在缺血解除后24小时达到最大值，血清肌红蛋白浓度中位数为565微克/升（范围：132 - 2688微克/升），血清肌酸磷酸激酶活性中位数为457 U/升（范围：190 - 1602 U/升）。血清肌红蛋白和肌酸磷酸激酶的升高与下肢动脉钳夹时间无关。用β2 - 微球蛋白血清浓度评估，这些患者未发现肾功能损害。
