Section for Orofacial Pain and Jaw Function, Department of Dental Medicine, Karolinska Institutet, P.O. Box 4064, 141 04 Huddinge, Sweden.
Faculty of Medicine, Umm al-Qura University, Jeddah 21452, Saudi Arabia.
Mediators Inflamm. 2013;2013:597419. doi: 10.1155/2013/597419. Epub 2013 Dec 9.
To investigate the impact of temporomandibular joint (TMJ) pain on daily activities and quality of life in relation to systemic inflammatory activity in patients with rheumatoid arthritis (RA), thirty-three consecutive outpatients with RA were included. TMJ pain intensity at rest, on maximum mouth opening, and on chewing was assessed on a 0-10 numerical rating scale. TMJ palpatory tenderness, degree of anterior open bite, the impact of TMJ pain on daily activities and quality of life were also assessed. The systemic inflammatory activity was estimated by the disease activity score 28 (DAS28), blood levels of inflammatory markers and number of painful musculoskeletal regions. TMJ pain at rest, on maximum mouth opening, and on chewing as well as DAS28 was correlated with the impact of the TMJ pain on daily activities and quality of life. Partial correlations showed a significant interaction between TMJ pain on movement and DAS28 that explained the TMJ pain impact on daily activities and quality of life to a significant degree. This study indicates that both current TMJ pain intensity and systemic inflammatory activity play roles in the impact of TMJ pain on daily living and quality of life in RA.
为了研究类风湿关节炎(RA)患者颞下颌关节(TMJ)疼痛对日常活动和生活质量的影响与全身炎症活动之间的关系,纳入了 33 名连续的 RA 门诊患者。采用 0-10 数字评分量表评估静息时、最大张口时和咀嚼时的 TMJ 疼痛强度。还评估了 TMJ 触压痛、前牙开颌程度、TMJ 疼痛对日常活动和生活质量的影响。通过疾病活动评分 28(DAS28)、炎症标志物的血液水平和疼痛肌肉骨骼区域的数量来评估全身炎症活动。静息时、最大张口时和咀嚼时的 TMJ 疼痛以及 DAS28 与 TMJ 疼痛对日常活动和生活质量的影响相关。偏相关显示 TMJ 运动时疼痛与 DAS28 之间存在显著的相互作用,这在很大程度上解释了 TMJ 疼痛对日常活动和生活质量的影响。本研究表明,当前 TMJ 疼痛强度和全身炎症活动均在 RA 患者 TMJ 疼痛对日常生活和生活质量的影响中起作用。