替加环素对从生物样本中分离出的耐甲氧西林金黄色葡萄球菌的活性评估
Evaluation of Tigecycline Activity Against Methicillin-Resistante Staphylococcus aureus Isolated from Biological Samples.
作者信息
Khalili Hossein, Dashti-Khavidaki Simin, Khaleghi Shahryar, Maleki Zohreh, Rasoolinejad Mehrnaz
机构信息
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pathology, Valiasr laboratory, Imam Khomini Hospital, Tehran, Iran.
出版信息
Iran J Pharm Res. 2010 Winter;9(1):61-5.
Tigecycline is a new glycylcycline antibiotic structurally similar to minocycline antibiotic. It has broad spectrum activity, including Staphylococcus aureus infections. This is the first study that evaluated the activity of Tigecycline against Staphylococcus aureus isolated from biological samples in Iran. In vitro activity of tigecycline against 160 Staphylococcus aureus including 99 methicillin-resistant S. aureus and 61 methicillin-susceptible S. aureus from inpatients at Imam Khomeini Hospital, Tehran, Iran was assessed. Bacterial susceptibility tests were performed by the disk diffusion method and also E-test for methicillin-resistant S. aureus isolates. All isolated had inhibition zone of ≥ 19 mm, with the minimum inhibitory concentration 50 (MIC50) and MIC90 of 0.19 and 0.5 μg/mL, respectively. The study results indicated that all methicillin-resistant S. aureus and methicillin-susceptible S. aureus isolates were susceptible to tigecycline.
替加环素是一种新型的甘氨酰环素类抗生素，其结构与米诺环素抗生素相似。它具有广谱活性，包括对金黄色葡萄球菌感染有效。这是第一项评估替加环素对从伊朗生物样本中分离出的金黄色葡萄球菌活性的研究。评估了替加环素对来自伊朗德黑兰伊玛目霍梅尼医院住院患者的160株金黄色葡萄球菌（包括99株耐甲氧西林金黄色葡萄球菌和61株甲氧西林敏感金黄色葡萄球菌）的体外活性。通过纸片扩散法进行细菌药敏试验，并对耐甲氧西林金黄色葡萄球菌分离株进行E试验。所有分离株的抑菌圈均≥19 mm，最低抑菌浓度50（MIC50）和MIC90分别为0.19和0.5μg/mL。研究结果表明，所有耐甲氧西林金黄色葡萄球菌和甲氧西林敏感金黄色葡萄球菌分离株均对替加环素敏感。
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