Zhang Lingmin, Tian Xiufen
Department of Otorhinolaryngology Head and Neck Surgery,First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Aug;27(15):815-7.
To investigate the expression of glucose-regulated protein78 (GRP78) in human laryngeal squamous cell carcinoma,and to evaluate its role in the development progress of human laryngeal squamous cell carcinoma.
The expressions of GRP78 in human laryngeal squamous cell carcinoma, matched pair pericarcinomatous tissue and normal laryngeal squamous epithelial tissue from 90 patients were detected using immunohistochemistry analysis. In addition, the relationship between GRP78 expression and clinical parameters of patients, such as gender, tumor differentiation grade stage, and lymphatic metastasis was analyzed.
The positive ratio of GRP78 expression in LSCC, matched pair pericarcinomatous tissue and normal laryngeal squamous epithelial tissue were 86.67%, 32.22% and 8.89%. The GRP78 expressions in different tissues were significantly different (P < 0.05). GRP78 expression in LSCC tissues was correlated with the grade of differention (P < 0.05), stage of tumors (P < 0.05), and lymphatic metastasis (P < 0.05), but not with gender (P > 0.05).
The expression level of GRP78 protein in human laryngeal squamous cell carcinoma is high and its expression is positively associated with the malignancy of carcinoma. The expression of GRP78 protein participates in the development progress of human laryngeal squamous cell carcinoma.
探讨葡萄糖调节蛋白78（GRP78）在人喉鳞状细胞癌中的表达情况，并评估其在人喉鳞状细胞癌发生发展过程中的作用。
采用免疫组化分析法检测90例患者的人喉鳞状细胞癌组织、配对癌旁组织及正常喉鳞状上皮组织中GRP78的表达情况。此外，分析GRP78表达与患者临床参数（如性别、肿瘤分化程度、分期及淋巴转移）之间的关系。
GRP78在喉鳞状细胞癌、配对癌旁组织及正常喉鳞状上皮组织中的阳性表达率分别为86.67%、32.22%和8.89%。不同组织中GRP78的表达存在显著差异（P < 0.05）。喉鳞状细胞癌组织中GRP78的表达与分化程度（P < 0.05）、肿瘤分期（P < 0.05）及淋巴转移（P < 0.05）相关，但与性别无关（P > 0.05）。
人喉鳞状细胞癌中GRP78蛋白表达水平较高，且其表达与肿瘤恶性程度呈正相关。GRP78蛋白的表达参与了人喉鳞状细胞癌的发生发展过程。
