[微生物基因组缩减与修饰的进展]
[Advances in microbial genome reduction and modification].
作者信息
Wang Jianli, Wang Xiaoyuan
出版信息
Sheng Wu Gong Cheng Xue Bao. 2013 Aug;29(8):1044-63.
PMID:24364343
Abstract
Microbial genome reduction and modification are important strategies for constructing cellular chassis used for synthetic biology. This article summarized the essential genes and the methods to identify them in microorganisms, compared various strategies for microbial genome reduction, and analyzed the characteristics of some microorganisms with the minimized genome. This review shows the important role of genome reduction in constructing cellular chassis.
摘要
微生物基因组的缩减与修饰是构建用于合成生物学的细胞底盘的重要策略。本文总结了微生物中的必需基因及其鉴定方法，比较了各种微生物基因组缩减策略，并分析了一些基因组最小化的微生物的特征。这篇综述展示了基因组缩减在构建细胞底盘中的重要作用。
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