Mater Sci Eng C Mater Biol Appl. 2012 Aug 1;32(6):1690-4. doi: 10.1016/j.msec.2012.04.069. Epub 2012 May 4.
Novel lidocaine containing calcium phosphate bone cements have been developed. Lidocaine release kinetics of these cements have been evaluated. Calcium phosphate cements have a great potential for local drug delivery. Release of local anesthetic, such as lidocaine, at the implant site can be useful for reducing pain immediately after implantation. In this work a local anesthetic - lidocaine hydrochloride - was incorporated into α-tricalcium phosphate cement. Lidocaine release profile was dependent on cement components used. All cements were characterized by an initial burst release, which can be correlated with cement pH values, followed by gradual drug release. Drug release continued for up to 6 days and was slower, if cement pH was higher. Addition of lidocaine hydrochloride accelerated setting and changed microstructure of the set cement.
新型含利多卡因的磷酸钙骨水泥已经研发出来。这些骨水泥的利多卡因释放动力学已经得到评估。磷酸钙骨水泥在局部药物输送方面具有很大的潜力。在植入部位释放局部麻醉剂（如利多卡因）可以在植入后立即减轻疼痛。在这项工作中，局部麻醉剂 - 盐酸利多卡因 - 被掺入到 α-磷酸三钙水泥中。利多卡因的释放曲线取决于所用的水泥成分。所有水泥均表现出初始突释，这与水泥 pH 值相关，随后是药物的逐渐释放。药物释放持续长达 6 天，如果水泥 pH 值更高，则释放速度更慢。添加盐酸利多卡因会加速凝固并改变凝固水泥的微观结构。
