Mater Sci Eng C Mater Biol Appl. 2012 Aug 1;32(6):1704-9. doi: 10.1016/j.msec.2012.04.045. Epub 2012 Apr 28.
We describe here a transformative approach to synthesize a hybrid nanostructured drug carrier that exhibits the characteristics of controlled drug release. The synthesis of the nanohybrid architecture involved two steps. The first step involved direct crystallization of biocompatible copolymer along the long axis of the carbon nanotubes (CNTs), followed by the second step of attachment of drug molecule to the polymer via hydrogen bonding. The extraordinary inorganic-organic hybrid architecture exhibited high drug loading ability and is physically stable even under extreme conditions of acidic media and ultrasonic irradiation. The temperature and pH sensitive characteristics of the hybrid drug carrier and high drug loading ability merit its consideration as a promising carrier and utilization of the fundamental aspects used for synthesis of other promising drug carriers. The higher drug release response during the application of ultrasonic frequency is ascribed to a cavitation-type process in which the acoustic bubbles nucleate and collapse releasing the drug. Furthermore, the study underscores the potential of uniquely combining CNTs and biopolymers for drug delivery.
我们在这里描述了一种变革性的方法来合成一种具有控制药物释放特性的混合纳米结构药物载体。该纳米杂化结构的合成涉及两个步骤。第一步涉及生物相容性共聚物沿着碳纳米管（CNT）的长轴直接结晶，然后第二步通过氢键将药物分子连接到聚合物上。这种非凡的无机-有机杂化结构表现出高药物负载能力，即使在酸性介质和超声辐射等极端条件下也具有物理稳定性。该混合药物载体的温度和 pH 敏感性以及高药物负载能力使其有望成为一种有前途的载体，并利用其在合成其他有前途的药物载体方面的基本方面。在超声频率的应用中，药物释放响应更高，这归因于空化型过程，其中声气泡成核并崩溃释放药物。此外，该研究强调了将碳纳米管和生物聚合物独特地结合用于药物输送的潜力。
