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[细菌的抗原多糖。21. 7种铜绿假单胞菌免疫型脂多糖的O-特异性多糖链结构及血清学特异性]

[Antigenic polysaccharides of bacteria. 21. The structure of O-specific polysaccharide chains and serological specificity of lipopolysaccharides from 7 Pseudomonas aeruginosa immunotypes].

作者信息

Knirel' Iu A, Kocharova N A, Vinogradov E V, Paramonov N A, Dmitriev B A

出版信息

Bioorg Khim. 1987 Jan;13(1):88-96.

PMID:2436629
Abstract

On mild acid degradation on lipopolysaccharides of seven Pseudomonas aeruginosa immunotypes, O-specific polysaccharides were obtained and their structures established. A peculiar feature of the polysaccharides is the presence of various, mostly acidic, mono- and diaminosugars, many of which have not previously been found in nature. The absence of serological cross-reactions (inhibition of passive haemagglutination) between lipopolysaccharides of seven immunotypes correlates with the absence of any common oligosaccharide fragments in their O-specific chains. The data obtained revealed structural and serological interrelations between O-antigens of seven immunotypes and P. aeruginosa O-serotypes, and showed that immunotypes 1 and 7 should be included into the serological classification scheme as individual O-serotypes.

摘要

对七种铜绿假单胞菌免疫型的脂多糖进行温和酸降解后,获得了O-特异性多糖并确定了其结构。这些多糖的一个独特特征是存在各种主要为酸性的单糖和二氨基糖,其中许多以前在自然界中未被发现。七种免疫型的脂多糖之间不存在血清学交叉反应(被动血凝抑制),这与它们的O-特异性链中不存在任何共同的寡糖片段相关。所获得的数据揭示了七种免疫型的O抗原与铜绿假单胞菌O血清型之间的结构和血清学相互关系,并表明免疫型1和7应作为单独的O血清型纳入血清学分类方案。

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