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[辣根过氧化物酶在烧伤性角膜炎时三叉神经逆行运输的动态变化]

[Dynamics of the retrograde transport of horseradish peroxidase in the trigeminal nerve during burn keratitis].

作者信息

Nikol'skiĭ V S

出版信息

Biull Eksp Biol Med. 1987 Apr;103(4):399-400.

PMID:2436680
Abstract

The dynamics of trigeminal neuron labelling with horseradish peroxidase (HRP) has been studied in rats during thermal burn keratitis. HRP application on the cornea after burn prolongs the time of its appearance in the perikarya cells of trigeminal ganglia, decreasing the number of labelled neurons. A more marked inflammation led to the decline in the number of nervous cells containing HRP. The decreased number of labelled HRP cells was recorded during the regeneration phase. This difference in the dynamics of neuron labelling in trigeminal ganglia was associated with the damaging effect of high temperature and inflammation on HRP uptake and transportation.

摘要

在大鼠热烧伤性角膜炎期间,对用辣根过氧化物酶(HRP)标记三叉神经元的动力学进行了研究。烧伤后将HRP应用于角膜,会延长其在三叉神经节周核细胞中出现的时间,减少标记神经元的数量。更明显的炎症会导致含有HRP的神经细胞数量下降。在再生阶段记录到标记的HRP细胞数量减少。三叉神经节中神经元标记动力学的这种差异与高温和炎症对HRP摄取和运输的破坏作用有关。

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