微波辅助合成 5,6-二氢吲哚并[1,2-a]喹喔啉衍生物：通过铜催化的分子内 N-芳基化反应。
Microwave-assisted synthesis of 5,6-dihydroindolo[1,2-a]quinoxaline derivatives through copper-catalyzed intramolecular N-arylation.
机构信息
CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China.
出版信息
Beilstein J Org Chem. 2013 Nov 14;9:2463-9. doi: 10.3762/bjoc.9.285. eCollection 2013.
Abstract
An efficient and practical protocol has been developed to synthesize 5,6-dihydroindolo[1,2-a]quinoxaline derivatives by CuI-catalyzed intramolecular N-arylation under microwave irradiation. This method rapidly afforded the tetracyclic products with good to excellent yields (83-97%) in short reaction times (45-60 min).
摘要
已开发出一种高效实用的方法，通过微波辐射下 CuI 催化的分子内 N-芳基化反应来合成 5,6-二氢吲哚并[1,2-a]喹喔啉衍生物。该方法在短反应时间（45-60 分钟）内以良好至优异的收率（83-97%）快速得到四环产物。
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