普瑞巴林中毒时出现的异常摇头和位置性下跳性眼球震颤。
Perverted head-shaking and positional downbeat nystagmus in pregabalin intoxication.
作者信息
Choi Jeong-Yoon, Park Young-Min, Woo Yeon Sun, Kim Sung Un, Jung Jin-Man, Kwon Do-Young
机构信息
Department of Neurology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, South Korea.
Department of Neurology, Korea University College of Medicine, Korea University Anam Hospital, Seoul, South Korea.
出版信息
J Neurol Sci. 2014 Feb 15;337(1-2):243-4. doi: 10.1016/j.jns.2013.12.007. Epub 2013 Dec 10.
Dizziness and ataxia are known adverse effects of pregabalin, but characteristic oculomotor signs in pregabalin intoxication have not been reported. Here we describe a patient who displayed perverted head-shaking and positional downbeat nystagmus after prescription of a high dosage of pregabalin. Since pregabalin reduces excitatory neurotransmitter secretion in the central nervous system, decreased excitatory inputs from the brainstem may lead to cerebellar dysfunction, causing perverted head-shaking and positional downbeat nystagmus.
头晕和共济失调是已知的普瑞巴林的不良反应，但普瑞巴林中毒时特征性的眼球运动体征尚未见报道。在此，我们描述一名患者，在服用高剂量普瑞巴林后出现了异常的摇头和位置性下跳性眼球震颤。由于普瑞巴林可减少中枢神经系统中兴奋性神经递质的分泌，来自脑干的兴奋性输入减少可能导致小脑功能障碍，从而引起异常的摇头和位置性下跳性眼球震颤。
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