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2
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7
Use of platelet lysate for bone regeneration - are we ready for clinical translation?血小板裂解物在骨再生中的应用——我们是否准备好进行临床转化？
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Simvastatin improves the homing of BMSCs via the PI3K/AKT/miR-9 pathway.辛伐他汀通过 PI3K/AKT/miR-9 通路改善 BMSCs 的归巢。
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本文引用的文献

1
Intra-subject variability in human bone marrow stromal cell (BMSC) replicative senescence: molecular changes associated with BMSC senescence.人类骨髓间充质干细胞（BMSC）复制性衰老的个体内变异性：与BMSC衰老相关的分子变化。
Stem Cell Res. 2013 Nov;11(3):1060-73. doi: 10.1016/j.scr.2013.07.005. Epub 2013 Jul 27.
2
Secreted galectin-3 as a possible biomarker for the immunomodulatory potential of human umbilical cord mesenchymal stromal cells.分泌型半乳糖凝集素-3 作为人脐带间充质基质细胞免疫调节潜力的潜在生物标志物。
Cytotherapy. 2013 Oct;15(10):1208-17. doi: 10.1016/j.jcyt.2013.05.011. Epub 2013 Jul 11.
3
Cost-effectiveness and budget impact study of solvent/detergent (SD) treated plasma (octaplasLG®) versus fresh-frozen plasma (FFP) in any patient receiving transfusion in Canada.加拿大接受输血的任何患者中，溶剂/去污剂（SD）处理血浆（OctaplasLG®）与新鲜冰冻血浆（FFP）的成本效益和预算影响研究。
Transfus Apher Sci. 2014 Aug;51(1):25-34. doi: 10.1016/j.transci.2013.04.045. Epub 2013 May 23.
4
Production of human platelet lysate by use of ultrasound for ex vivo expansion of human bone marrow-derived mesenchymal stromal cells.利用超声制备人血小板裂解液用于人骨髓间充质基质细胞的体外扩增。
Cytotherapy. 2013 Aug;15(8):920-9. doi: 10.1016/j.jcyt.2013.01.219. Epub 2013 Apr 24.
5
Concise review: mesenchymal stem cells and translational medicine: emerging issues.简明综述：间充质干细胞与转化医学：新出现的问题。
Stem Cells Transl Med. 2012 Jan;1(1):51-8. doi: 10.5966/sctm.2011-0019. Epub 2011 Dec 7.
6
Generation of a pool of human platelet lysate and efficient use in cell culture.人血小板裂解物库的生成及其在细胞培养中的高效应用。
Methods Mol Biol. 2013;946:349-62. doi: 10.1007/978-1-62703-128-8_22.
7
Prostaglandin E2: a putative potency indicator of the immunosuppressive activity of human mesenchymal stem cells.前列腺素E2：人类间充质干细胞免疫抑制活性的一种假定效力指标。
Am J Stem Cells. 2012 Jun 30;1(2):138-145. Epub 2012 May 18.
8
Comparison of endometrial regenerative cells and bone marrow stromal cells.子宫内膜再生细胞与骨髓基质细胞的比较。
J Transl Med. 2012 Oct 5;10:207. doi: 10.1186/1479-5876-10-207.
9
The establishment of a bank of stored clinical bone marrow stromal cell products.建立储存式临床骨髓基质细胞产品库。
J Transl Med. 2012 Feb 6;10:23. doi: 10.1186/1479-5876-10-23.
10
Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy.间充质基质细胞治疗的长期并发症、免疫效应和传代对结局的作用。
Biol Blood Marrow Transplant. 2012 Apr;18(4):557-64. doi: 10.1016/j.bbmt.2011.07.023. Epub 2011 Aug 4.

在国立卫生研究院临床中心建立骨髓基质细胞移植项目。

Establishing a bone marrow stromal cell transplant program at the National Institutes of Health Clinical Center.

机构信息

1 Department of Transfusion Medicine, Clinical Center, National Institutes of Health , Bethesda, Maryland.

出版信息

Tissue Eng Part B Rev. 2014 Jun;20(3):200-5. doi: 10.1089/ten.TEB.2013.0529. Epub 2014 Feb 7.

DOI:10.1089/ten.TEB.2013.0529
PMID:24368014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4030651/
Abstract

A repository of cryopreserved bone marrow stromal cell (BMSC) products prepared from marrow aspirates of healthy subjects has been created and is being used to treat patients with inflammatory bowel disease, cardiovascular disease, and acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. New methods of manufacturing BMSCs are being investigated including the use of an automated bioreactor for BMSC expansion and the replacement of fetal bovine serum with human platelet lysate as a media supplement. Efforts are also being made to identify markers that can be used to assess the potency of BMSCs.

摘要

已建立了一个冷冻保存的骨髓基质细胞（BMSC）产品库，这些产品是从健康供体的骨髓抽吸物中制备的，用于治疗炎症性肠病、心血管疾病和异基因造血干细胞移植后急性移植物抗宿主病的患者。目前正在研究新的 BMSC 制造方法，包括使用自动化生物反应器进行 BMSC 扩增，以及用人血小板裂解物替代胎牛血清作为培养基补充。此外，还正在努力确定可用于评估 BMSC 效力的标志物。