Saad C, Dooley C P, Valenzuela J E
Dig Dis Sci. 1987 May;32(5):487-93. doi: 10.1007/BF01296031.
In addition to gastric mucosal cytoprotective and antisecretory effects, prostaglandin E2 has a beneficial effect on experimental pancreatitis in some animal models, while prostaglandin synthesis inhibitors such as indomethacin and salicylates may induce pancreatitis at maximal doses. However, their effect on human pancreas is unclear. For this reason we considered it necessary to delineate their actions on human pancreatic secretion. Six healthy volunteers were studied on six separate days. On day 1, against a background of 1 pmol/kg/hr secretin, increasing doses of CCK were infused intravenously. On day 2, increasing doses of an amino acid mixture were infused intraduodenally and both studies were repeated on two occasions, following 100 micrograms 15(R), 15-methyl prostaglandin E2 per os on one and following indomethacin 50 mg orally 12 and 1 hr prior to the study on the other. Both indomethacin and PGE2 had no significant effect on pancreatic secretion in response to graded doses of CCK. 15(R),15-Methyl prostaglandin E2 and indomethacin caused a reduction of amylase output in response to the higher doses of intraduodenal amino acids. The prostaglandin E2 derivative also elicited a significant increase in basal bicarbonate output.
the acute effects of 15(R),15-methyl prostaglandin E2 and indomethacin on human pancreatic secretion do not seem to offer an explanation for the mechanisms of protection against experimental acute pancreatitis or an association with pancreatitis, respectively.
除了对胃黏膜有细胞保护和抑制分泌的作用外，前列腺素E2在一些动物模型中对实验性胰腺炎有有益作用，而吲哚美辛和水杨酸盐等前列腺素合成抑制剂在最大剂量时可能诱发胰腺炎。然而，它们对人体胰腺的作用尚不清楚。因此，我们认为有必要描述它们对人体胰腺分泌的作用。六名健康志愿者在六个不同的日子接受研究。在第1天，在每小时1皮摩尔/千克的促胰液素背景下，静脉注射递增剂量的胆囊收缩素。在第2天，十二指肠内注射递增剂量的氨基酸混合物，两项研究均重复两次，一次在口服100微克15(R)，15-甲基前列腺素E2之后，另一次在口服50毫克吲哚美辛后12小时和研究前1小时。吲哚美辛和前列腺素E2对分级剂量胆囊收缩素刺激的胰腺分泌均无显著影响。15(R)，15-甲基前列腺素E2和吲哚美辛使对较高剂量十二指肠内氨基酸刺激的淀粉酶分泌量减少。前列腺素E2衍生物还使基础碳酸氢盐分泌量显著增加。
15(R)，15-甲基前列腺素E2和吲哚美辛对人体胰腺分泌的急性作用似乎分别无法解释其对实验性急性胰腺炎的保护机制或与胰腺炎的关联。
