Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, MTFS, Postbox 8905, 7491 Trondheim, Norway ; Department of Anesthesiology and Intensive Care Medicine, Trondheim University Hospital, Postbox 3250 Sluppen, 7006 Trondheim, Norway.
Invivosense Norway Ltd., c/o NTNU Technology Transfer, Sem Saelands Vei 14, 7034 Trondheim, Norway.
Int J Endocrinol. 2013;2013:245152. doi: 10.1155/2013/245152. Epub 2013 Nov 27.
The aim of this study was to construct a glucose regulatory algorithm by employing the natural pulsatile pattern of insulin secretion and the oscillatory pattern of resting blood glucose levels and further to regulate the blood glucose level in diabetic pigs by this method. We developed a control algorithm based on repetitive intravenous bolus injections of insulin and combined this with an intravascular blood glucose monitor. Four anesthetized pigs were used in the study. The animals developed a mildly diabetic state from streptozotocin pretreatment. They were steadily brought within the blood glucose target range of 4.5-6.0 mmol/L in 21 to 121 min and kept within that range for 128 to 238 min (hypoglycemic values varied from 2.9 to 51.1 min). The study confirmed our hypotheses regarding the feasibility of this new principle for blood glucose control, and the algorithm was constantly improved during the study to produce the best results in the last animals. The main obstacles were the drift of the IvS-1 sensor and problems with the calibration procedure, which calls for an improvement in the sensor stability before this method can be applied fully in new studies in animals and humans.
本研究旨在构建一种葡萄糖调节算法，通过利用胰岛素分泌的自然脉冲模式和静息血糖水平的波动模式，以此方法调节糖尿病猪的血糖水平。我们开发了一种基于重复静脉推注胰岛素的控制算法，并将其与血管内血糖监测器相结合。本研究使用了 4 头麻醉猪。动物通过链脲佐菌素预处理发展为轻度糖尿病状态。它们在 21 到 121 分钟内逐渐达到 4.5-6.0mmol/L 的血糖目标范围，并在 128 到 238 分钟内保持在该范围内（低血糖值从 2.9 到 51.1 分钟不等）。该研究证实了我们关于该新血糖控制原理的可行性的假设，并且在研究过程中不断改进算法，以在最后几只动物中取得最佳结果。主要障碍是 IvS-1 传感器的漂移和校准程序的问题，这需要在该方法在动物和人类的新研究中充分应用之前，提高传感器的稳定性。
