Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Anesthesiology. 2011 Jan;114(1):120-5. doi: 10.1097/ALN.0b013e3181ff4187.
Tight blood glucose control is used extensively in perioperative and critically ill patients. Several studies, however, have shown contradictory effects on patient outcomes. A major problem of these studies has been inadequate control of the prime variable, blood glucose. This paper describes the validation of a new intravascular continuous blood glucose sensor.
The glucose sensor was placed in the superior caval vein of seven anesthetized pigs. Sensor readings were compared with arterial blood gas readings. Fluctuations in blood glucose were created using intravenous glucose and insulin. A total of 807 paired sensor and blood gas readings were obtained.
The sensor was tested with a range of blood glucose values (0.63-15.75 mM [mean bias, 0.0131 mM]). Analysis using Bland-Altman plots yielded 95% limits of agreement at -0.908 and 0.934 mM. There were 121 paired measurements with a mean value below 2.2 mM, yielding 95% limits of agreement at -0.553 and 0.466 mM.
The performance of the sensor was in agreement with blood gas measurements in a wide range of glucose values. For the clinician, it is noteworthy that performance was equally good in the hypoglycemic area.
在围手术期和危重病患者中广泛使用严格的血糖控制。然而，几项研究表明，这对患者的结局有相反的影响。这些研究的一个主要问题是血糖这一主要变量控制不足。本文介绍了一种新型血管内连续血糖传感器的验证。
将葡萄糖传感器放置在七只麻醉猪的上腔静脉中。传感器读数与动脉血气读数进行比较。通过静脉内葡萄糖和胰岛素来产生血糖波动。共获得 807 对传感器和血气读数。
传感器在一系列血糖值（0.63-15.75mM[平均偏差，0.0131mM]）下进行了测试。使用 Bland-Altman 图进行分析得出 95%的一致性界限在-0.908 和 0.934mM。有 121 对平均值低于 2.2mM 的配对测量，得出 95%的一致性界限在-0.553 和 0.466mM。
传感器的性能与血气测量在广泛的血糖范围内一致。对临床医生来说，值得注意的是，在低血糖区域的性能同样良好。
