储存血液流变学特性的改变作为血液碳灌注中红细胞功能状态的标准。

Alterations in rheologic properties of stored blood as criterion of the functional state of erythrocytes in haemocarboperfusion.

作者信息

Nicolaev V G, Sigal V L, Belkin A L, Osadchiy P V, Lunco A A

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1986;113(6):790-8.

Abstract

Rheologic studies performed on rotational viscometers "Rheotest-2" and "VIR-78" within shear rates gamma interval of 0.1 s-1 less than gamma less than 1,312 s-1, revealed a substantial reduction in dynamic viscosity of the blood subjected to sorption treatment on activated charcoal. The importance of volume concentration of erythrocytes proper for dynamic viscosity is analysed. Special emphasis is placed on the necessity to take into account the dispersion of electrophoretic mobility of erythrocytes in analyzing surface properties of erythrocytes from stored blood before and after hemocarboperfusion. In addition, the normalization of electrosurface characteristics of erythrocytes and associated with them the aggregational property of blood after its purification by sorption is demonstrated. The restoration of the explored physical and chemical characteristics of blood, perfused through the sorbent, permits its more valuable transfusional medium to be considered in comparison to conventional stored blood with identical times of preservation.

摘要

在旋转粘度计“Rheotest - 2”和“VIR - 78”上进行的流变学研究，在剪切速率γ的区间为0.1 s⁻¹＜γ＜1312 s⁻¹内，揭示了经活性炭吸附处理的血液的动态粘度大幅降低。分析了适合动态粘度的红细胞体积浓度的重要性。特别强调在分析血液灌流前后储存血液中红细胞的表面特性时，有必要考虑红细胞电泳迁移率的离散性。此外，还证明了红细胞电表面特性的归一化以及与之相关的吸附净化后血液的聚集特性。与具有相同保存时间的传统储存血液相比，通过吸附剂灌注的血液所探索的物理和化学特性的恢复，使其成为更有价值的输血介质。