Dal Bo Zanon R, Calzavara M, Vicari T, Miotti A, Girolami A
Folia Haematol Int Mag Klin Morphol Blutforsch. 1986;113(6):799-804.
125 dental extractions were performed in patients with hemophilia A, B, von Willebrand disease and rare coagulopathies. The missing factor was brought to a level of 15-40% according to the degree of surgical trauma. In the majority of cases a single pre-extraction administration of concentrate was sufficient. Antifibrinolytics were administered to the patients (tranexamic acid, 60 mg/kg/day) for 8-10 days. After tooth extraction, a fibrin sponge was positioned using anti-traumatic cross suture. In 90% of cases there was no bleeding, in the others modest easily controllable hemorrhagic episodes. Our results show that it is sufficient in hemophilia A and B to use low doses of antihemophilic concentrate (10-20 U/kg) and frequently a single pre-extraction administration. In rare coagulopathies the hemostatic procedure and dental management have also to be similar to those used in hemophilia A and B.
对患有甲型血友病、乙型血友病、血管性血友病和罕见凝血障碍的患者进行了125次拔牙手术。根据手术创伤程度，将缺失的凝血因子水平提高到15%-40%。在大多数情况下，术前单次注射浓缩物就足够了。给患者使用抗纤维蛋白溶解剂（氨甲环酸，60毫克/千克/天），持续8-10天。拔牙后，使用抗创伤交叉缝合放置纤维蛋白海绵。90%的病例没有出血，其他病例有轻微的、易于控制的出血情况。我们的结果表明，对于甲型和乙型血友病，使用低剂量的抗血友病浓缩物（10-20单位/千克）且通常术前单次注射就足够了。在罕见凝血障碍中，止血程序和牙科处理也必须与甲型和乙型血友病所用的方法相似。
