深静脉血栓形成患者中因子 XIII 的分子亚基及转酰胺酶活性

Molecular subunits and transamidase activity of factor XIII in patients with deep vein thrombosis.

作者信息

Kłoczko J, Wojtukiewicz M, Bielawiec M

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1986;113(6):810-4.

Abstract

Thrombin formed during the clotting process leads to the activation of factor XIII and then to its consumption. Transamidase activity of factor XIII and its concentrations of subunits "a" and "b" were measured in plasmas of patients with deep vein thrombosis of the calves. The patients revealed a significant decrease of both factor XIII activity and its concentration of subunit "a". A subsequent rise of transamidase activity and concentration of subunit "a" of factor XIII to the normal values was observed in two weeks' time. It is assumed that estimation of factor XIII activity and/or its concentration of subunit "a" may be an additional method for detecting venous thrombosis and monitoring its therapy.

摘要

凝血过程中形成的凝血酶会导致因子 XIII 激活，进而导致其消耗。在患有小腿深静脉血栓形成的患者血浆中，测定了因子 XIII 的转酰胺酶活性及其亚基“a”和“b”的浓度。这些患者显示因子 XIII 活性及其亚基“a”的浓度均显著降低。两周后观察到因子 XIII 的转酰胺酶活性和亚基“a”的浓度随后上升至正常值。据推测，因子 XIII 活性和/或其亚基“a”的浓度测定可能是检测静脉血栓形成及其治疗监测的一种额外方法。