对慢性尿毒症患者经鼻给予1-去氨基-8-D-精氨酸加压素后出血时间缩短。

Shortening of bleeding time after intranasal administration of 1-deamino-8-D-arginine vasopressin to patients with chronic uremia.

作者信息

Rydzewski A, Rowiński M, Myśliwiec M

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1986;113(6):823-30.

Abstract

1-deamino-8-D-arginine vasopressin (DDAVP) was administered intranasally in a dose of 2 micrograms/kg BW to 17 uremic patients (16 maintained on chronic hemodialysis and 1 treated conservatively). The bleeding time was significantly shortened 120 minutes after DDAVP administration (from 18.1 +/- 7.5 minutes to 12.3 +/- 6.4 minutes p less than 0.001). Factor VIII related antigen (VIII: Ag) did not change. Factor VIII ristocetin cofactor activity (VIII: RCof) significantly increased (from 251.2 +/- 162.0 to 336.5 +/- 167.2 p less than 0.025). Platelet count decreased significantly after DDAVP (from 174.9 +/- 43.8 X 10(9)/l to 155.6 +/- 45.9 X 10(9)/l 30 minutes p less than 0.01 and 129.8 +/- 45.2 X 10(9)/l p less than 0.005 120 minutes after DDAVP). Antithrombin III concentration, and hematocrit did not change. Our data indicate that further clinical studies of intranasal DDAVP in uremic patients during episodes of bleeding are warranted.

摘要

对17例尿毒症患者（16例维持性慢性血液透析患者和1例保守治疗患者）经鼻给予剂量为2微克/千克体重的1-去氨基-8-D-精氨酸加压素（DDAVP）。给予DDAVP 120分钟后出血时间显著缩短（从18.1±7.5分钟缩短至12.3±6.4分钟，p<0.001）。凝血因子VIII相关抗原（VIII:Ag）未改变。凝血因子VIII瑞斯托霉素辅因子活性（VIII:RCof）显著增加（从251.2±162.0增至336.5±167.2，p<0.025）。给予DDAVP后血小板计数显著下降（给药30分钟后从174.9±43.8×10⁹/升降至155.6±45.9×10⁹/升，p<0.01；给药120分钟后降至129.8±45.2×10⁹/升，p<0.005）。抗凝血酶III浓度和血细胞比容未改变。我们的数据表明，有必要对尿毒症患者出血发作期间经鼻给予DDAVP进行进一步的临床研究。