The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.
Public Health England, Porton Down, Porton, Salisbury, UK.
Tuberculosis (Edinb). 2014 Mar;94(2):105-10. doi: 10.1016/j.tube.2013.11.003. Epub 2013 Dec 1.
There is an urgent need for an improved TB vaccine. Vaccine development is hindered by the lack of immune correlates and uncertain predictive value of preclinical animal models. As data become available from human efficacy trials, there is an opportunity to evaluate the predictive value of the criteria used to select candidate vaccines. Here we review the efficacy in animal models of the MVA85A candidate vaccine in light of recent human efficacy data and propose refinements to the preclinical models with the aim of increasing their predictive value for human efficacy.
目前迫切需要一种改良型结核疫苗。由于缺乏免疫相关因素，以及临床前动物模型的预测价值不确定，疫苗研发受到阻碍。随着来自人体疗效试验的数据不断增加，我们有机会评估用于选择候选疫苗的标准的预测价值。本文根据最近的人体疗效数据，综述了 MVA85A 候选疫苗在动物模型中的疗效，并提出对临床前模型进行改进，以期提高其对人体疗效的预测价值。
