Su Guo-Hong, Zhao Yu-Lei
The Second Department of Hematology, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China. E-mail:
The Second Department of Hematology, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Dec;21(6):1631-4. doi: 10.7534/j.issn.1009-2137.2013.06.050.
CD47 is a ubiquitously expressed transmembrane glycoprotein on surface of many cells. Through its interaction with integrin, signal regulatory protein alpha (SIRPα) and thrombin sensitive protein-1 (TSP-1), it plays important roles in various immunological processes including inflammatory response, immune response and tumor immunity. Recently, it has been found that CD47 interacts with SIRPα expressed on phagocytic cells, which transfers a negative signal when being activated. By the mechanisms described above, CD47-SIRPα signal complex is involved in the pathogenesis of hematological diseases and might provide some informations for the therapy of patients. This review focuses on the structure and immunoregulatory functions of CD47, the mechanism of CD47 in tumor therapy, the CD47 and hematologic malignancies including acute leukemia, B-cell lymphoma and multiple myeloma, as well as CD47 and hematopoietic stem cell transplantation.
CD47是一种在许多细胞表面普遍表达的跨膜糖蛋白。通过与整合素、信号调节蛋白α（SIRPα）和凝血酶敏感蛋白-1（TSP-1）相互作用，它在包括炎症反应、免疫反应和肿瘤免疫在内的各种免疫过程中发挥重要作用。最近，人们发现CD47与吞噬细胞上表达的SIRPα相互作用，SIRPα被激活时会传递负信号。通过上述机制，CD47-SIRPα信号复合体参与血液系统疾病的发病机制，并可能为患者的治疗提供一些信息。本文综述聚焦于CD47的结构和免疫调节功能、CD47在肿瘤治疗中的机制、CD47与血液系统恶性肿瘤（包括急性白血病、B细胞淋巴瘤和多发性骨髓瘤）以及CD47与造血干细胞移植。
