使用基质辅助激光解吸/电离飞行时间质谱法对树枝状聚乙二醇和聚乙二醇多臂星的特性进行表征。
The characterization of dendronized poly(ethylene glycol)s and poly(ethylene glycol) multi-arm stars using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
机构信息
Tulane University, Department of Chemistry, 2015 Percival Stern Hall, 6400 Freret Street, New Orleans, LA 70118, USA.
Tulane University, Department of Chemistry, 2015 Percival Stern Hall, 6400 Freret Street, New Orleans, LA 70118, USA.
出版信息
Anal Chim Acta. 2014 Jan 15;808:175-89. doi: 10.1016/j.aca.2013.09.038. Epub 2013 Oct 1.
The synthesis of branched poly(ethylene glycol) (PEG) derivatives, namely star PEG and dendronized PEG, can be challenging and their purity can be difficult to ascertain using traditional techniques, such as NMR and GPC. Herein, the detailed characterization of these branched PEGs using MALDI-ToF MS was investigated in order to confirm their structural purity. In this light, mass spectrometry offers a number of advantages for polymer characterization, including the ability to get detailed structural data, such as end group masses, from microgram-scale samples. In addition, the ability to rapidly acquire data from crude reaction aliquots makes MALDI-ToF MS ideal for monitoring end group transformations.
支化聚乙二醇（PEG）衍生物的合成，即星形 PEG 和树枝状 PEG，可能具有挑战性，并且其纯度使用传统技术（如 NMR 和 GPC）难以确定。在此，通过 MALDI-ToF MS 对这些支化 PEG 进行了详细的表征，以确认其结构纯度。在这方面，质谱法为聚合物特性分析提供了许多优势，包括能够从小规模样品中获得详细的结构数据，如端基质量。此外，从粗反应等分试样中快速获取数据的能力使 MALDI-ToF MS 成为监测端基转化的理想选择。
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