血栓素A2合成酶抑制剂对速发型超敏反应的影响。

Effect of thromboxane A2 synthetase inhibitor on immediate-type hypersensitivity reactions.

作者信息

Nakagawa T, Miyamoto T, Urata C, Mano K, Yukawa T, Makino S

出版信息

Int Arch Allergy Appl Immunol. 1987;82(3-4):539-40. doi: 10.1159/000234273.

Abstract

The effect of the thromboxane (TX) A2 synthetase inhibitor, OKY-046, on human leukocyte histamine release and bronchial hypersensitivity in asthmatic subjects was evaluated. It was found that OKY-046 inhibited IgE- and Ca2+ ionophore A23187-mediated leukocyte histamine release in a dose-dependent fashion (IC50: 1.0 and 3.0 X 10(-3) M, respectively) and that OKY-046 could diminish bronchial hypersensitivity, determined by leukotriene D4 inhalation, following a 2-week oral medication. These data suggest that the TXA2 synthetase inhibitor can produce favorable effects upon the course of immediate-type hypersensitivity reactions.

摘要

评估了血栓素（TX）A2合成酶抑制剂OKY - 046对哮喘患者人白细胞组胺释放和支气管超敏反应的影响。发现OKY - 046以剂量依赖性方式抑制IgE和钙离子载体A23187介导的白细胞组胺释放（IC50分别为1.0和3.0×10⁻³ M），并且在口服给药2周后，OKY - 046可减轻由白三烯D4吸入所测定的支气管超敏反应。这些数据表明，TX A2合成酶抑制剂可对速发型超敏反应过程产生有利影响。