Department of Radiology, University of South Florida, Morsani College of Medicine, 2 Tampa General Cir, STC 7035, Tampa, FL 33606-3571 USA. E-mail address:
J Ultrasound Med. 2014 Jan;33(1):129-34. doi: 10.7863/ultra.33.1.129.
The purpose of this study was to determine whether the elasticity imaging/B-mode ratio on strain elastography can predict breast cancer tumor grades.
A retrospective review of patients with breast lesions who underwent strain elastography and had a diagnosis of breast cancer by image-guided or surgical biopsy was performed. The axis of the maximum elastographic dimension was compared to the B-mode dimension to form an elasticity imaging/B-mode ratio. Lesions were categorized according to their pathologic type, including atypical ductal hyperplasia (ADH), mucinous or colloid cancer, ductal carcinoma in situ (DCIS), grade I invasive ductal carcinoma (IDC), grade II IDC, grade III IDC, invasive lobular carcinoma (ILC), and lymphoma. The mean elasticity imaging/B-mode ratio of each tumor type was calculated. The elasticity imaging/B-mode ratio of the tumor was compared to the tumor type by Kruskal-Wallis and Tukey-Kramer tests (lymphoma and ADH excluded because of small numbers).
Tumor grades included lymphoma (n = 3), ADH (n = 2), mucinous cancer (n = 11), DCIS (n = 19), IDC (grades I-III; n = 200), and ILC (n = 31). The mean elasticity imaging/B-mode ratio varied with increasing tumor grade. Tumor grades could not have been selected at random from one population (P < .0001, χ(2) test). Invasive lobular carcinoma and grade III IDC were statistically different from mucinous or colloid cancer, DCIS, and grade I and II IDC.
The elasticity imaging/B-mode ratio on strain elastography is related to the tumor grade.
本研究旨在确定应变弹性成像的弹性成像/ B 模式比是否可以预测乳腺癌肿瘤分级。
对接受应变弹性成像检查且经影像引导或手术活检诊断为乳腺癌的患者进行回顾性研究。将最大弹性成像维度的轴与 B 模式维度进行比较，形成弹性成像/ B 模式比。根据病理类型对病变进行分类，包括非典型导管增生（ADH）、黏液或胶样癌、导管原位癌（DCIS）、I 级浸润性导管癌（IDC）、II 级 IDC、III 级 IDC、浸润性小叶癌（ILC）和淋巴瘤。计算每种肿瘤类型的平均弹性成像/ B 模式比。通过 Kruskal-Wallis 和 Tukey-Kramer 检验（由于数量较少，排除了淋巴瘤和 ADH）比较肿瘤的弹性成像/ B 模式比与肿瘤类型。
肿瘤分级包括淋巴瘤（n = 3）、ADH（n = 2）、黏液癌（n = 11）、DCIS（n = 19）、I-III 级 IDC（n = 200）和 ILC（n = 31）。随着肿瘤分级的增加，平均弹性成像/ B 模式比也随之增加。肿瘤分级不可能从一个群体中随机选择（P <.0001，卡方检验）。浸润性小叶癌和 III 级 IDC 在统计学上与黏液或胶样癌、DCIS 和 I 级和 II 级 IDC 不同。
应变弹性成像的弹性成像/ B 模式比与肿瘤分级有关。
