Anghel Daniela, Tanasescu Radu, Campeanu Ana, Lupescu Ioana, Podda Giulio, Bajenaru Ovidiu
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Fundeni Clinical Institute, Department of Neurology, Bucharest, Romania.
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Fundeni Clinical Institute, Department of Neurology, Bucharest, Romania ; University of Nottingham, Academic Division of Clinical Neurology, Nottingham, UK.
Maedica (Bucur). 2013 Jun;8(2):170-5.
Immunosuppressive agents have revolutionized clinical transplantation medicine, allowing the avoidance of immune system attack on the transplanted graft. Nevertheless, the use of medications such as cyclosporine, tacrolimus and others also brought the side effects of these drugs. Early identification of drug-induced neurotoxicity in transplanted patients and of its specific causes is important, not only because of patient's poor clinical status but because of concomitant systemic and metabolic disorders which may obscure symptoms. Treatment and prognosis are highly dependent on the type of complication and it's early recognition. This review focuses on the clinical entities of neurotoxicity caused by immunosuppressive drugs in transplanted patients.
免疫抑制剂彻底改变了临床移植医学，使移植的移植物免受免疫系统攻击。然而，使用环孢素、他克莫司等药物也带来了这些药物的副作用。早期识别移植患者药物诱导的神经毒性及其具体原因很重要，这不仅是因为患者临床状况不佳，还因为可能掩盖症状的伴随全身性和代谢性疾病。治疗和预后高度依赖于并发症的类型及其早期识别。本综述重点关注移植患者中免疫抑制药物引起的神经毒性的临床实体。
